Sleep Disorders in Huntington ’s Disease

ConclusionsDifferent patterns of sleep disturbances are observed in HD patients: insomnia, difficulties in falling asleep, frequent nocturnal awakenings, and excessive daytime sleepiness are the most common sleep problems reported by patients with HD. In several HD studies, specific changes in sleep architecture and in circadian melatonin secretion were identified in laboratory testing.Sleep disorders in HD have diverse and complex determinants, the most significant of which includes damage to brain areas that are responsible for the proper sleep pattern and circadian rhythm regulation. Sleep and circadian rhythm disorders in HD might also be associated with psychiatric disorders, especially depression, mania, and anxiety disorders. Another group of factors related to sleep disturbances in HD are involuntary movements and increased motor activity during sleep, and other motor disturbances. Moreover, the pattern of sleep disorders in HD is often altered by the many drugs used to alleviate the core symptoms of the disease, a substantial number of which may adversely affect sleep.Therefore, studies on sleep disorders in HD are associated with numerous difficulties, as is also the case with other neurodegenerative diseases. However, identification of sleep disorders and more comprehensive recognition of their causes are necessary to ensure adequate care and treatment for patients. Disorders of sleep and the circadian rhythm in patients with HD can contribute to exacerbation of sy...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Publication date: Available online 11 November 2019Source: Journal of Prosthodontic ResearchAuthor(s): Ana C. Cadore-Rodrigues, Luís F. Guilardi, Vinicius F. Wandscher, Gabriel K.R. Pereira, Luiz F. Valandro, Marília P. RippeAbstractPurposeTo compare the effect of different surface treatments (pre-treatments and bonding agents) on the bond strength between glass-fiber post and composite resin, and the topographic alterations of the treated post surface.MethodsThirty-six glass-fiber blocks (12 mm × 10 mm × 8 mm) were specifically manufactured for this study and ra...
Source: Journal of Prosthodontic Research - Category: Dentistry Source Type: research
Conclusions We present a quick, simple, and affordable method to decellularize a muscle flap through the vascular network. Our proposed method is efficient and can be completed in a significantly shorter time when compared with other methods. It is also safe and does not affect integrity of tissue, and this is essential for a reliable recellularization.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Transplantation Surgery and Research Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Integrative MedicineAuthor(s): Sajjad Sadeghi, Farzaneh Ghaffari, Ghazaleh Heydarirad, Mehdi AlizadehAbstractGalen (129–199 A.D.), an ancient Greek scholar, is one of the most influential and recognized physicians and surgeons in the history of medicine. He is one of the most influential Greek scholar in Persian medicine, which has been repeatedly cited by Iranian scholars. The purpose of this article is to describe the exact position of Galen in Avicenna’s The Canon of Medicine, the most important work of Persian medicine. In The Canon of Me...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionsIn this high-risk low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Graphical abstract
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
In conclusion, participants suggest that tailored secondary prevention programming that acknowledges and targets the unique exercise, psychological, and peer support needs of patients with SCAD, as well as increased education for healthcare providers, may be integral to promote patients in their recovery.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Objective: To compare the effects of a high-fidelity simulator and conventional teaching model used during blood pressure measurement training on students’ self-confidence, self-efficacy and anxiety levels. Methods: A randomized controlled trial design was used. The study was conducted on 59 first-year nursing students of a university in Amasya, Turkey. ‘Self-Confidence Scale,’ ‘general Self-Efficacy Scale’ and ‘Beck Anxiety Scale’ were used to collect the data. A high-fidelity simulator used in blood pressure measurement training was applied to the experimental group, while t...
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophysiology Source Type: research
This study presents an exploratory characterization on the effect of build orientation on deformation behavior of Ti–6Al–4V rods produced through electron beam melting (EBM). Microstructural differences in horizontally and vertically printed rods were characterized using optical microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) coupled with energy dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). A typical microstructure of the alloy consists of primary-α and vanadium-enriched β phases. Compared to the horizontal samples, vertically print...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: Available online 11 November 2019Source: Materials Science and Engineering: AAuthor(s): Lei Dai, Zhong Liu, Liming Yu, Yongchang Liu, Zengmin ShiAbstractFe–9Cr ODS alloys elaborated by mechanical milling (MM) and followed by hot isostatic pressing (HIP) and hot rolling (HR) have been studied using transmission electron microscopy (TEM) and atom probe tomography (APT) to understand their microstructural characterization. The as-HIP alloy exhibited equiaxed ferrite and contained nanoparticles and low density of dislocations. The as-HR alloy manifested elongated ferrite and contained nanoclusters and h...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
This study investigated microstructure formation as a function of orientation-dependent surface tension anisotropy during directional solidification of Al-4.5%Cu alloy. Axial dendrites (AD), tilted dendrite (TD), and degenerate pattern (DP) were identified in the solidified microstructures of the single crystals. A single-crystal specimen with a stable DP, which was characterized by successive splitting tips, was carefully prepared and specifically investigated. The corresponding mechanical properties were compared with those of single-crystal AD and TD specimens. The ductility and toughness of the single-crystal specimen ...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Hojjat Naji, Jafar Khalil-Allafi, Vida KhaliliAbstractThe present work was aimed to quantitatively analyze the phases in the Ni-rich NiTi shape memory alloy which was aged at different temperatures of 470, 500 and 530 °C for 11, 38, 196 and 536 h. The aging treatment was done while applying various stress values. The phase transformation behavior of prepared specimens was analyzed using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) at ambient temperature and 75 °C. The weight percent of the dif...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
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