Altered Local and Large-Scale Dynamic Functional Connectivity Variability in Posttraumatic Stress Disorder: A Resting-State fMRI Study

In this study, we compared the dynamic resting-state local and large-scale FC between PTSD patients (n = 22) and healthy controls (HC; n = 22; conducted as standard deviation in resting-state local and large-scale FC over a series of sliding windows). Local dynamic FC was examined by calculating the dynamic regional homogeneity (dReHo), and large-scale dynamic FC (dFC) was investigated between regions with significant dReHo group differences. For the PTSD patients, we also investigated the relationship between symptom severity and dFC/dReHo. Our results showed that PTSD patients were characterized by I) increased dynamic (more variable) dReHo in left precuneus (PCu); II) increased dynamic (more variable) dFC between the left PCu and left insula; and III) decreased dFC between left PCu and left inferior parietal lobe (IPL), and decreased dFC between left PCu and right PCu. However, there is no significant correlation between the clinical indicators and dReHo/dFC after the family-wise-error (FWE) correction. These findings provided the initial evidence that PTSD is characterized by aberrant patterns of fluctuating communication within brain system such as the default mode network (DMN) and among different brain systems such as the salience network and the DMN.IntroductionPosttraumatic stress disorder (PTSD) is a psychiatric condition that can emerge after exposure to an exceedingly traumatic event (1). In the general population, PTSD occurs most commonly after traffic accidents...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Kakarla Raghava Reddy, Pattubala Adinaraya Reddy, Chandragiri Venkata Reddy, Nagaraj P. Shetti, Bhatula Babu, Koutavarapu Ravindranadh, Muthukonda Venkatakrishnan Shankar, Madhava C. Reddy, Sarvesh Soni, Shivalingegowda NaveenAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most extensively used functional nanomaterials as antibacterial agents, and for other biomedical applications due to their unique physical, chemical, magnetic and biocompatibility properties. However, due to their small size, particles tend to aggregate by dipo...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
In this work, the four optimum azimuthal angles are determined for a full-Stokes scanning polarimeter comprising a rectangular prism, quarter-wave plate, and four linear polarizers. The determinant and condition numbers of the measurement matrix are used as objective functions in an optimization ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
CONCLUSIONS: The minimum rim width and retinal nerve fibre layer thickness measurements using the Anatomic Positioning System protocol had overall excellent reproducibility and diagnostic performance. Using this protocol and the novel minimum rim width parameter may be useful in more accurate diagnosis and follow-up of patients with glaucoma. PMID: 31109473 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
CONCLUSIONS: Based on the literature, best practice guidelines, and a cost analysis, it was decided that patients undergoing routine cataract surgery in Edmonton Zone Hospitals under regional anaesthesia would no longer require physician history and physicals and ECGs. Elimination of the preoperative requirements for all but select high-risk patients meant that 100% of patients who arrived for cataract surgery would not have outstanding presurgery requirements. PMID: 31109469 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
Source: Redox Biology - Category: Biology Source Type: research
Authors: Korn L, Hassan K, Fainshtein N, Yusov N, Davidovitch N Abstract BACKGROUND Non-medical use of prescription stimulants (NPS) for treatment of attention deficit hyperactivity disorders (ADHD), which are considered narcotic substances and medical drugs, are used to treat learning and attention disorders. The purpose of this study was to investigate associations between misuse of medications for treatment of ADHD and various characteristics and problem behaviors, such as impulsivity, deviant behavior, and drug use. MATERIAL AND METHODS A total of 1280 undergraduate students (64% females; mean age 27; SD=6) com...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS Catheter-directed thrombolysis is a reliable and safe treatment modality for postnatal or abortion patients with DVT. CDT can reduce the incidence rate of PTS and increase the quality of life. PMID: 31110168 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Esfahanian M, Ghasemzadeh MA, Razavian SMH Abstract Today, metal-organic frameworks (MOFs) for the release of drugs have been studied extensively. In this research, we have investigated the novel magnetic framework including Fe3O4@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. Moreover, the antibacterial activity of Fe3O4@PAA@ZIF-8 and Fe3O4@PAA@ZIF-8@CIP screened against Staphylococcus aureus ( S. aureus) and Escherichia coli ( E. coli) bacteria. The structure of the nano carrier, as well as the encapsulation of the drug in the framework was confirmed by the Fourier-transform infrared spect...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
In this study, polysaccharides were extracted using different techniques including ultrasound-assisted extraction (UA), cellulase-assisted extraction (CA), cellulase-ultrasound-assisted extraction (CUA) and pectinase-ultrasound-assisted extraction (PUA) from Fritillaria pallidiflora Schrenk. Extraction yields, chemical composition, physicochemical, structural properties and antioxidant activities of the polysaccharides were compared. Results shows that polysaccharides extracted with CUA method has the highest extraction yield (20.65 ± 0.78%), including carbohydrate (56.16 ± 0.38%) ...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: Available online 21 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Parisa Sufi-Maragheh, Nasser Nikfarjam, Yulin Deng, Nader Taheri-QazviniAbstractIn this paper, we report the use of amphiphilic crosslinked starch nanoparticles (CSTNs) as biocompatible, biodegradable and effective stabilizer for Pickering emulsion formulation. The nearly monodispersed CSTNs ( ˜ 140 nm) were synthesized through alkali-freezing method followed by crosslinking using citric acid. The prepared nanoparticles were characterized by field emission scanning electron microscopy, zeta-potential measurem...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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