68Ga tagged dendrimers for molecular tumor imaging in animals.

68Ga tagged dendrimers for molecular tumor imaging in animals. Hell J Nucl Med. 2019 Jan-Apr;22(1):78-79 Authors: Wei X, Liu Z, Zhao Z Abstract Dear Editor, Angiogenesis is an essential physiological process that involves formation of new blood vessels from the pre-existing ones and is one of the fundamental processes required for normal growth and development. The ability to non-invasively evaluate angiogenesis might provide new insights into cancer biology pathway. This approach might lead to opportunities to more appropriately select patients likely to respond to anti-angiogenic drugs. Polyamidoamine dendrimers are a member of a versatile, new class of dendritic polymers and are the most well characterized and widely used polymers. In the present study we have utilized them for imaging of a crucial process of angiogenesis in a cancer model of mice. Amongst, several PET radionuclides, there has been a renewed interest in 68Ga for many reasons. Gallium-68 is well suited for use as a radiolabel for PET because of its comparatively shorter half-life of 68min. The emission of two divergent photons per decay allows the construction of three-dimensional images. Furthermore, the advances in generator technology for 68Ga production and its favorable chemistry for radiocomplexation have paved the way for emerging applications of 68Ga radiopharmaceuticals. A recent study reported the blood pharmacokinetics of different generations of PAMAM dendrimers (generations...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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ConclusionsOur results indicate that PEITC targets HER2-positive CSCs and that its combination with trastuzumab may pave the way for a novel therapeutic strategy for HER2-positive tumors.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
Abstract A 52-year-old woman experienced severe headache, confusion, nausea, dizziness, and diplopia for three days. Magnetic resonance imaging of the brain showed multiple acute and subacute infarcts suggestive of embolic events. Dermatological examination was notable for splinter hemorrhages and macular patches on the fingernails and feet, respectively. Further diagnostic imaging of the chest and abdomen revealed pulmonary emboli and an ovarian mass with omental deposits and splenic infarcts. Fine needle aspiration cytology and surgery confirmed a diagnosis of high grade serous adenocarcinoma of the ovary with c...
Source: Clin Med Res - Category: Research Authors: Tags: Clin Med Res Source Type: research
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Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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