Understanding tissue-engineered endochondral ossification; towards improved bone formation.

Understanding tissue-engineered endochondral ossification; towards improved bone formation. Eur Cell Mater. 2019 Apr 10;37:277-291 Authors: Knuth C, Kiernan C, Wolvius E, Narcisi R, Farrell E Abstract Endochondral ossification (EO) is the process by which the long bones of the body form and has proven to be a promising method in tissue engineering for achieving cell-mediated bone formation. The present review centred on state-of-the-art research pertaining to mesenchymal stem cells (MSCs)-mediated endochondral bone formation, focusing on the role of donor cells, extracellular matrix and host immune cells during tissue-engineered bone formation. Possible research avenues to improve graft outcome and bone output were highlighted, as well as emerging research that, when applied to tissue-engineered bone grafts, offers new promise for improving the likelihood of such grafts transition from bench to bedside. PMID: 30968944 [PubMed - in process]
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research