The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals

Conclusion In summary, this study shows a decline of the in vivo oxidative capacity of skeletal muscle with age in an extremely healthy population, which indicates that this decline is not due to a disease process but rather to aging. Additionally, the significant correlation between resting muscle perfusion and whole-body aerobic capacity mediated by muscle oxidative capacity, independent of age, suggests new interventions that improve muscle perfusion might attenuate mitochondrial dysfunction with aging as well as the age-associated decline of aerobic capacity and frailty in sarcopenic and older adults. Ethics Statement This study was carried out in accordance with the recommendations of “the IRB of the National Institute of Environmental Health Science (Research Triangle Park, North Carolina)” with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the “IRB of the National Institute of Environmental Health Science.” Author Contributions FA, DC, CB, KF, RS, DR, and LF were involved in the study conception, and design. FA, DR, and LF performed the collection of and/or analysis of data. FA and LF wrote the manuscript. All the authors approved the final version of the manuscript. Funding This work was funded by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, United S...
Source: Frontiers in Physiology - Category: Physiology Source Type: research