10 New Drugs for Primary Care: Q1 2019

Highlights:  The first liquid solution of colchicine for prophylaxis of gout, the first generic version of Advair Diskus,® and 8 more new and approved drugs.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: ADHD Asthma COPD Depression Gout Headache and Migraine HIV AIDS Source Type: news

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Osborne H Abstract The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycationic peptides, and protons. The CaSR plays a critical role in extracellular calcium (Ca2+ o) homeostasis, as demonstrated by the many naturally occurring mutations in the CaSR or its signaling partners that cause Ca2+ o homeostasis disorders. However, CaSR tissue expression in mammals is broad and includes tissues unrelated to Ca2+ o homeostasis, ...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
Publication date: Available online 30 May 2020Source: European Journal of Integrative MedicineAuthor(s): Jingyi Shao, Lingming Zhou, Tianyu Shao, Minrui Ding, Zhuqing Jin
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 30 May 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Adeeb B. Bulkhi, Kirk V. Shepard, Thomas B. Casale, Juan Carlos Cardet
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 30 May 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Gianluca Serafini, Giovanna Canepa, Andrea Aguglia, Andrea Amerio, Davide Bianchi, Magnani, Bernardo Dell'Osso, Maurizio Pompili, Paul B. Fitzgerald, Mario Amore
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
HIGH blood pressure symptoms can be difficult to spot, but may include severe headaches, chest pain, and finding blood in your urine. You could lower your chances of deadly hypertension symptoms and signs by smelling lavender oil, it's been claimed. Should you check your blood pressure?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This article summarizes the possibilities of systemic antihistamines in pruritus, especially with regard to limitations and future prospects. PMID: 32468293 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Authors: Kupczyk M, Baiardini I, Molinengo G, Loera B, Szydłowska D, Kuna P, Canonica GW, Braido F Abstract Introduction: The RhinAsthma Patient Perspective (RAPP) was developed in Italian to assess the Health Related Quality of Life (HRQoL) impairment in patients with asthma and allergic rhinitis (AR) in daily practice. Aim: To cross-culturally validate the Polish version. Material and methods: The Polish version was administered to patients suffering from asthma and rhinitis in a prospective observational study. Polish RAPP, along with SF-12, ACT, and a Symptomatologic VAS was filled in twice, with a 4-w...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Conclusions: Increasing building age and certain indoor heating methods are important risk factors for the occurrence of allergic rhinitis and asthma. PMID: 32467689 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Authors: Bernatowicz PL, Golec P, Bielecki P, Kowal K Abstract Introduction: The CD163 is exclusively expressed by mononuclear phagocytes as a transmembrane protein, which synthesis is regulated by anti- and pro-inflammatory signals. After shedding from the cell surface it exists in body fluids as a soluble protein (sCD163) which exerts anti-inflammatory effects. Aim: To evaluate serum concentration and ex vivo production of sCD163 by peripheral blood mononuclear cells (PBMC) in asthmatic patients treated with inhaled (ICS) or oral corticosteroids (OCS). Material and methods: The study was performed on 35 a...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Authors: Nowicki RJ, Trzeciak M, Kaczmarski M, Wilkowska A, Czarnecka-Operacz M, Kowalewski C, Rudnicka L, Kulus M, Mastalerz-Migas A, Peregud-Pogorzelski J, Sokołowska-Wojdyło M, Śpiewak R, Adamski Z, Czuwara J, Kapińska-Mrowiecka M, Kaszuba A, Krasowska D, Krêcisz B, Narbutt J, Majewski S, Reich A, Samochocki Z, Szepietowski J, Woźniak K Abstract Atopic dermatitis is a chronic and recurrent inflammatory dermatosis with concomitant intensive pruritus, and is diagnosed both in children and adults. Atopic dermatitis-patients are predisposed to have bacterial, viral and fungal skin infections; they also su...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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