Aerobic exercise and Orexin A: role of sympathetic activity and redox system.
Aerobic exercise and Orexin A: role of sympathetic activity and redox system. J Biol Regul Homeost Agents. 2019 Apr 10;33(2) Authors: Monda V, Villano I, Messina A, Valenzano A, Salerno M, Santo Signorelli S, Monda M, Russo V, Sessa F, Messina G Abstract Aerobic exercise is associated with the sympathetic activation evoking adaptive responses to sustain muscle engagement. Physical exercise can cause alterations in the cardiovascular activity and cellular stress may occur which could be marked by either heart rate (HR), or galvanic skin response (GSR). Moderate plasma levels of reactive oxygen species (ROS) are considered as health markers, absolving to important roles such as adaptive cellular responses to exercise. Orexin A, a hypothalamic peptide, causes a widespread stimulation of the sympathetic nervous system, playing a role in many physiological functions. PMID: 30968680 [PubMed - as supplied by publisher]
Conclusion: AMSS sessions were effective in reducing BP, increasing baroreflex sensitivity and decreasing cardiovascular sympathetic modulation in Parkinson's disease patients. AMSS might be useful to control supine hypertension in Parkinson's disease.
This study exemplifies the key link that specifically connects the efferent sympathetic signal with the spleen innate immunity.Graphical Abstract
This case report describes a severe adverse event following antisense oligonucleotide treatment for muscular dystrophy that occurred in 6 pediatric patients.
We describe a robust strategy for DM1 PGT-M that can be applied to virtually any at-risk couple. This strategy utilizes whole-genome amplification, followed by triplet-primed PCR (TP-PCR) detection of expanded DMPK alleles, in parallel with single-tube haplotype analysis of 12 closely linked and highly polymorphic microsatellite markers. Bidirectional TP-PCR and dodecaplex marker PCR assays were optimized and validated on whole-genome amplified single lymphoblasts isolated from DM1 reference cell lines, and tested on a simulated PGT-M case comprising a parent-offspring trio and three simulated embryos. Bidirectional DMPK T...
Even though genetic studies of individuals with neuromuscular diseases have uncovered the molecular background of many cardiac disorders such as cardiomyopathies and inherited arrhythmic syndromes, the genetic cause of a proportion of cardiomyopathies associated with neuromuscular phenotype still remains unknown. Here, we present a clinical case with a combination of cardiomyopathy and limb-girdle type muscular dystrophy where whole exome sequencing identified myoferlin (MYOF) – a member of the Ferlin protein family and close homolog of DYSF - as the most likely candidate gene. The disease-causative role of the ident...
ConclusionsStress score and sympathetic/parasympathetic ratio seem to be the best HRV predictors of internal load. Although there are no differences in HRV during recovery at the same time points in both conditions, the recovery is slower after exercise in HH than in HD.
In this study, we present a novel approach for inducing vasoconstriction by pulsed electrical treatment delivered via endovascular electrodes, which can be used in cases where external access to the vessel is limited. Methods: Using computer simulations, we optimized various geometries of endovascular electrodes to maximize the induced electric field on the arterial wall. Using the optimal configuration parameters, we investigated endovascular induced vasoconstriction in both the carotid and femoral sheep arteries. Results: Endovascular electrodes induced robust vasoconstriction in the carotid artery of sheep, showing grad...
(AFM-T é l é thon) Ana Buj Bello's team, a researcher in an Inserm unit at Genethon, the AFM-Telethon laboratory, has made the proof-of-concept of a CRISPR-Cas9 approach in a mouse model of Steinert's myotonic dystrophy, the most common neuromuscular disease in adults.
There are several errors in the article Iwata M, Kondo I, Sato Y, Satoh K, Soma M, Bar-Or O. Prediction of reflex sympathetic dystrophy in hemiplegia by evaluation of hand edema, published in Archives of Physical Medicine and Rehabilitation 2002;83:1428-31 (https://doi.org/10.1053/apmr.2002.34830), Prediction of reflex sympathetic dystrophy in hemiplegia by evaluation of hand edema, contained several errors.
Conclusion: With the advancements in retinal imaging, atypical MHs are now more frequently recognized. With increasing understanding of the underlying disease processes, and improvement in investigations and surgical treatment, management of atypical MHs may improve in the future.