A Baby Was Born With DNA from 3 People. Here ’s How That’s Possible

Researchers at the Institute of Life in Athens, Greece announced that a healthy baby boy was born on Tuesday morning to a 32-year-old woman who had experienced several failed cycles of IVF. The six-pound boy, who the doctors say in a statement is healthy, was born using a technique called maternal spindle transfer. In the procedure, the grouped-together DNA from a mother’s egg was removed and placed inside a donor egg from another woman, which had been emptied of its DNA. The donor’s egg with the mother’s genes was then fertilized and developed into an embryo that was transferred for pregnancy. The technique takes advantage of the fact that something in the mother’s egg was preventing a viable embryo from forming when it was fertilized. Any number of factors could contribute to the problem, including poor quality of the egg to deficiencies in essential factors that a fertilized egg needs to begin dividing into an embryo. One of those factors is mitochondria, which are found in every human cell and lie outside of the nuclear DNA that contains a cell’s genes. With maternal spindle transfer, the donor’s mitochondria, along with other factors in the egg, presumably make it possible for the egg to then be fertilized and develop into an embryo. “We are now in a position to make it possible for women with multiple IVF failures or rare mitochondrial genetic diseases to have a healthy child,” said Dr. Panagiotis Psathas, president of th...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Genetics Reproductive Health Source Type: news

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Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized fertility Research Source Type: news
Conclusions: Concentrations of MnBP, MBzP and MEHP similar to those found in the urine of pregnant women consistently altered hCG and PPARγ expression in primary placental cells. These findings provide evidence for the molecular basis by which phthalates may alter placental function, and they provide a preliminary mechanistic hypothesis for opposite responses by sex. https://doi.org/10.1289/EHP1539 Received: 23 December 2016 Revised: 6 September 2017 Accepted: 18 September 2017 Published: 31 October 2017 Address correspondence to J.J. Adibi, 130 Desoto Street, Parran Hall 5132, Pittsburgh, PA 15261 USA. Telephone...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Infertility treatment is more common than ever, thanks to technology.  More than 70,000 babies were born through in-vitro fertilization in 2014, according to the latest Centers for Disease Control and Prevention data. That’s an increase of nearly 10,000 babies, compared with five years earlier. Men and women are increasingly likely to seek medical help for reasons that include reduced stigma and more employers offering coverage for IVF. But one big reason for the trend is clear: Fertility doctors are getting better at making babies. “Science is moving at a pace that’s very different th...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Authors: Bisht S, Dada R Abstract Oxidative stress (OS) has been implicated in a wide array of diseases such as neurodegenerative disorders, autoimmune diseases, complex lifestyle diseases and cancer. OS is caused by an imbalance in production of Reactive Oxygen Species (ROS) and antioxidant defenses in the cell which results in the damage of cellular components, inactivate essential metabolic enzymes and disrupt signal transduction pathways. OS induces peroxidative damage to the sperm plasma membrane, DNA fragmentation in sperm nuclear/mitochondrial genome and causes dysregulation in levels of mRNAs/transcripts. O...
Source: Frontiers in Bioscience - Scholar - Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Mitochondria are our cells' energy-producing powerhouses. Now, a Massachusetts company is convinced that these microscopic cylinders are also key to conceiving a baby, and several groups of physicians outside the United States are testing that controversial premise in women with fertility problems. More than 10 women are pregnant via the firm's proprietary in vitro fertilization (IVF) method, which adds a bolus of a woman's own mitochondria to her mature egg. Meanwhile, the Food and Drug Administration (FDA) has erected roadblocks in front of a fertility specialist and a stem cell biologist who want to clinically test a di...
Source: Science: Current Issue - Category: Science Authors: Tags: Reproductive Medicine Source Type: research
Abstract Mitochondrial dysfunction is implicated in disease and age-related infertility. Mitochondrial replacement therapies (MRT) in oocytes or zygotes, such as pronuclear (PNT), spindle (ST), or polar body (PBT) transfer, could prevent second-generation transmission of mitochondrial DNA (mtDNA) defects. PNT, associated with high levels of mtDNA carryover in mice but low levels in human embryos, carries ethical issues secondary to donor embryo destruction. ST, developed in primates, supports normal development to adults and low mtDNA carryover. PBT in mice, coupled with PN or ST, may increase the yield of reconst...
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research
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