Lawmakers in Both Parties Vow to Rein In Insulin Costs

A hearing on Wednesday was one of several signs that Congress was serious about trying to address the cries of distress from constituents unable to afford the medicines they need.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Diabetes Drugs (Pharmaceuticals) Prices (Fares, Fees and Rates) Health Insurance and Managed Care Insulin Source Type: news

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CONCLUSION: Bacteremia occurred mostly in active SLE patients and was frequently associated with severe flares and corticosteroid use. Recurrence and mortality were high. Immunosuppressors, comorbidities and disease-related damage were associated with bacteremia. PMID: 30988123 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Anand Thirupathi, Yan-Zhong ChangAbstractThe gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. In case of increased energy demands or insufficient nutrient supply, cells digest their own interior, which is called autophagy. AMPK-mediated autophagy regulates various metabolic and phys...
Source: Life Sciences - Category: Biology Source Type: research
Abstract Lifestyle and genetic factors contribute to the initiation of oxidative stress and inflammation in diabetes mellitus (DM). Oxidative stress and lipid peroxidation worked in an orchestrated manner and reported to be strongly associated with the formation of the hyperlipidemic condition in DM patients. Isoquercetin, a bioactive constituent isolated from guava leaves has attracted considerable attention because of its antidiabetic activity. The antidiabetic activity of guava leaves may be due to the presence of isoquercetin at a significant level. However, how isoquercetin regulates different pathways in DM ...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Expression and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific. Chem Biol Interact. 2019 Apr 25;303:57-61 Authors: Dammann C, Stapelfeld C, Maser E Abstract The microsomal enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts glucocorticoid receptor-inert cortisone (11-dehydrocorticosterone in rodents) to its receptor-active form cortisol (corticosterone in rodents). Thus, 11β-HSD1 amplifies glucocorticoid action at the tissue level. According to the current literature, dysregulation of glucocortico...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Publication date: Available online 16 April 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Huang Chen, Peng Sun, Meijia Qiu, Min Jiang, Jie Zhao, Dongxue Han, Li Niu, Guofeng CuiAbstractIn response to the challenges posed by diabetes, portable glucose sensors with enzyme-free catalytic materials have received great attention in recent years. Herein, a facile strategy for fabricating inexpensive and efficient electrochemical sensors is proposed. Flexible copper clad laminate (FCCL) can be firstly decorated with nanoporous copper (NP Cu) through electrodepositing Cu-Sn alloy and dealloying the Sn element. Then ...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
ConclusionsIncreasing dietary scores are supposed to have a provoking effect on disease condition resulting into worse outcomes at higher scores. The findings from nutritional biomarkers suggested that deficiently found nutrients must be supplemented as a part of therapy to enhance the treatment benefits.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
We examined associations between gestational diabetes mellitus and incidence of childhood- and youth-onset diabetes in offspring. METHODS: Using public health insurance administrative databases from Quebec, Canada, we randomly selected singleton live births with maternal gestational diabetes mellitus (1990-2007) and matched them 1:1 with singleton live births without gestational diabetes mellitus. Follow-up was to Mar. 31, 2012. We examined associations of diabetes in offspring with maternal gestational diabetes mellitus through unadjusted and adjusted Cox proportional hazards models. In secondary analyses, we separate...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Authors: Hyle EP, Bekker LG, Martey EB, Huang M, Xu A, Parker RA, Walensky RP, Middelkoop K Abstract INTRODUCTION: People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease (CVD). Screening for CVD risk factors is recommended but not routine in South African HIV clinics. We sought to describe the prevalence of CVD risk factors among antiretroviral treatment (ART)-experienced patients in South Africa. METHODS: We performed a prospective, observational cross-sectional study of PWH (>21 years, excluding pregnant women) on ART in South Africa. We interviewed patients regarding C...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Conclusions: These data suggest the hypothesis that the relative survival advantage of AA dialysis patients may be related toAPOL1 variation. Further large population-based genetic studies are required to test this hypothesis.Cardiorenal Med 2019;9:212 –221
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
Publication date: May 2019Source: The Lancet Global Health, Volume 7, Issue 5Author(s): Naaheed Mukadam, Andrew Sommerlad, Jonathan Huntley, Gill LivingstonSummaryBackgroundNine potentially modifiable risk factors (less childhood education, midlife hearing loss, hypertension, and obesity, and later-life smoking, depression, physical inactivity, social isolation, and diabetes) account for 35% of worldwide dementia, but most data to calculate these risk factors come from high-income countries only. We aimed to calculate population attributable fractions (PAFs) for dementia in selected low-income and middle-income countries (...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
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