Alberta women with breast implant illness urge doctors to warn others of risk

Women across Alberta are joining together to bring attention to breast implant illness, which they say caused them such severe autoimmune disease symptoms that they thought they were dying.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Edmonton Source Type: news

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In conclusion, the spectrum of autoimmune reactions induced by immune-checkpoint inhibitors should be restricted in the near future to only these specific favorable autoimmune mechanisms. In this way, the unnecessary autoimmune reactions/autoaggressions could be avoided (a better quality of life), and treatment specificity and efficiency should increase (a higher response rate for melanoma therapy).
Source: Melanoma Research - Category: Cancer & Oncology Tags: REVIEW ARTICLES Source Type: research
We report three cases of cutaneous lupus associated with pembrolizumab therapy for advanced melanoma. One patient had a previous diagnosis of histologically proven discoid lupus erythematosus, well-controlled without treatment for over 2 years, which flared on first exposure to pembrolizumab. The remaining two patients had no previous history of autoimmune disease; both developed cutaneous eruptions, histologically and immunohistologically, in keeping with subacute cutaneous lupus following treatment with pembrolizumab. Our report bolsters what is currently an exceedingly small body of evidence documenting the development ...
Source: Melanoma Research - Category: Cancer & Oncology Tags: SHORT COMMUNICATIONS Source Type: research
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system. A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development and maintenance of MS-related pain. This is important to consider, as MS is a predominantly female disease. Using the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, we demonstrate sex differences in measures of spinal cord inflammation and plasticity that accompany tactile hypersensitivity. Although we observed substa...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Abstract Inducible bronchus-associated lymphoid tissue (iBALT) is a tertiary lymphoid structure that resembles secondary lymphoid organs. iBALT is induced in the lung in response to Ag exposure. In some cases, such as infection with Mycobacterium tuberculosis, the formation of iBALT structure is indicative of an effective protective immune response. However, with persistent exposure to Ags during chronic inflammation, allergy, or autoimmune diseases, iBALT may be associated with exacerbation of inflammation. iBALT is characterized by well-organized T and B areas enmeshed with conventional dendritic cells, follicul...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
In conclusion, our results confirm the effects of belimumab on B cell subpopulations. These can be directly explained by the blockage of soluble BLyS interaction with BLyS-R. On the other hand, the effects on the composition of the T cell compartment are mild, which is not totally unexpected, since the intensity of BLyS-R expression by peripheral T cells is low (Ng et al., 2004). The principal limits of this study include the small sample size, presence of concomitant immunosuppressive therapies and low absolute cell number at baseline. Nevertheless, future studies on larger numbers of patients are needed to evaluate wheth...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions In this review, we collected all the information concerning the OMICs studies performed on HS patients aimed at unraveling the mechanisms at the basis of the disease or associated to clinical severity and/or the successful response to pharmacological treatment (including biological drugs). The general picture of the OMICs contribution in the context of HS is not so clear and/or rich of clinical useful information, since most of the studies focused only on one aspect (genome, transcriptome, or proteome) of the disease, enrolling small numbers of patients (this is quite limiting for the genetic studies) from di...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: This study indicates that the TCF7L2 gene variant is associated with AA. Its contribution to disease pathogenesis could either be through a hair cycling defect or dendritic cell dysregulation. PMID: 31012334 [PubMed - as supplied by publisher]
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
The grazing ruminants of the earth are able to obtain virtually all their nutrition from consuming grasses and forage. They harbor specific anatomic and physiologic adaptations developed over millions of years to do so. Humans have no such adaptations but are advised by all “official” sources of dietary advice to make grains–the seeds of grasses–the cornerstone of the diet. It means that there are numerous indigestible or only partially digestible proteins in wheat and grains that explain why autoimmune diseases, gastrointestinal disruption, and other health conditions are so commonly caused by whe...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: What is in wheat that's so bad? gluten-free grain-free grains Inflammation wheat belly Source Type: blogs
Conclusion Recent advances in research on HTLV-1 provide better understanding of the molecular pathogenesis and mechanisms of HAM/TSP, and several clinical trials of novel therapies for patients with HAM/TSP have been initiated. However, long-term improvement of motor disability and quality of life still have not been achieved in HAM/TSP patients, and the clinical management remains challenging. Given that HAM/TSP is characterized by activated T-cells in both the periphery and CNS, studies in HAM/TSP will be highly informative for clarifying the pathogenesis of other neuroinflammatory disorders such as multiple sclerosis....
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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