For frail elderly after heart attack, meds may prolong life but impact function

(Reuters Health) - - After a heart attack, frail older adults may live longer by taking several medications typically prescribed to prevent future heart problems, but the drugs might also contribute to increased frailty, a U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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CONCLUSIONS: Although diabetic status did not significantly interfere with treatment effects of guided DAPT de-escalation, our results suggest that this approach might be safe and effective in non-diabetic patients, whilst further investigation is definitely warranted in diabetic patients. PMID: 31012853 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Authors: Kogame N, Modolo R, Tomaniak M, Cavalcante R, de Martino F, Tinoco J, Ribeiro EE, Mehran R, Campos CM, Onuma Y, Lemos PA, Serruys PW, Collaborators Abstract AIMS: To demonstrate the feasibility and safety of prasugrel monotherapy without aspirin post procedure in selected patients undergoing successful percutaneous coronary intervention (PCI) with the SYNERGY stent. METHODS AND RESULTS: The ASET Pilot study is designed as a multicenter, single arm, open-label, proof-of-concept trial with a stopping rule based on the occurrence of definite stent thrombosis (def-ST). Two hundred patients with a SYNTAX score of
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
This article reviews relationships between mild to moderate essential hypertension and chronic kidney disease with a focus on the role of APOL1 in development of hypertension. Available evidence strongly supports that APOL1 renal-risk variants associate with glomerulosclerosis in African Americans, which then causes secondary hypertension, not with essential hypertension per se.
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: Available online 23 April 2019Source: The Lancet Global HealthAuthor(s): Annika Rosengren, Andrew Smyth, Sumathy Rangarajan, Chinthanie Ramasundarahettige, Shrikant I Bangdiwala, Khalid F AlHabib, Alvaro Avezum, Kristina Bengtsson Boström, Jephat Chifamba, Sadi Gulec, Rajeev Gupta, Ehi U Igumbor, Romaina Iqbal, Norhassim Ismail, Philip Joseph, Manmeet Kaur, Rasha Khatib, Iolanthé M Kruger, Pablo Lamelas, Fernando LanasSummaryBackgroundSocioeconomic status is associated with differences in risk factors for cardiovascular disease incidence and outcomes, including mortality. However, it is unclea...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
AbstractIntroductionAtherosclerotic cardiovascular disease (ASCVD) and Framingham risk scores (FRS) are used to calculate 10-year risk of coronary death, nonfatal myocardial infarction, or fatal/nonfatal stroke. Our goal is to evaluate the association between preoperative cardiovascular risk and weight loss.MethodsWe retrospectively reviewed bariatric surgeries from 2010 to 2016. Patients who met criteria for calculating 10-year ASCVD score and FRS were included. Data collected included baseline demographics, perioperative parameters, and postoperative outcomes at 12  months. Simple linear regression and multiple line...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
WEDNESDAY, April 24, 2019 -- For older patients with acute myocardial infarction (AMI), percutaneous coronary intervention (PCI) is beneficial across age strata, according to a research letter published online April 23 in Circulation: Cardiovascular...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Abstract Objectives: To investigate the influence of statins on major adverse cardiovascular events (MACE) in patients with coronary microvascular dysfunction (CMVD). Participants: 23,494 patients who received coronary angiography (CAG) were included. Thrombolysis in Myocardial Infarction, Myocardial Perfusion Grading (TMPG), a useful angiographic method, was used to evaluate CMVD. Results: Using multivariate analysis, NYHA III/IV (HR, 1.44; 95% CI, 1.03-2.01; P=0.031), PCI history (HR, 3.69; 95% CI, 2.57-5.31; P
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
New research in mice uses gene-regulating molecules called microRNAs to repair heart tissue after an adverse cardiovascular event such as a heart attack.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Heart Disease Source Type: news
We appreciate the interest in our article [1]. The authors raised the issue that ischemic conditioning (IC) may have also affected our study results of reduced myocardial injury and improved clinical outcome in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing direct stenting (DS) and recommend to include the IC intervention in our Cox regression analyses for identification of independent predictors of improved prognosis.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research
(University of California - San Diego) Researchers at University of California San Diego School of Medicine found using blood thinners in patients with worsening heart failure, coronary artery disease and irregular heart rhythms was associated with a reduced risk of thromboembolic events, such as stroke and heart attack.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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