Scientists believe they could DOUBLE survival time for pediatric brain cancer

A new study from Cincinnati Children's Hospital Medical Center has found that blocking a gene that helps glioblastoma grow and spread may increase survival time.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Professor Malcolm Sperrin - director of medical physics at Oxford University hospitals - explained studies that link mobiles and cancer are often carried out on mice that are exposed to extremely high levels of radiation.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Researchers here report on discovering that an existing farnesyltransferase inhibitor drug reverses the accumulation of altered tau protein aggregates in a mouse model. The death and dysfunction of nerve cells in the neurodegenerative conditions known as tauopathies is driven by the formation of neurofibrillary tangles, made of tau protein. That in turn has deeper causes, such as the chronic inflammation produced by senescent cells and disruption of immune cell activity in the central nervous system, one of which is no doubt being adjusted in some way by the action of the drug in this case. As in all such quite indirect me...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
AbstractAccurate and reliable brain tumor segmentation is a critical component in cancer diagnosis. According to deep learning model, a novel brain tumor segmentation method is developed by integrating fully convolutional neural networks (FCNN) and dense micro-block difference feature (DMDF) into a unified framework so as to obtain segmentation results with appearance and spatial consistency. Firstly, we propose a local feature to describe the rotation invariant property of the texture. In order to deal with the change of rotation and scale in texture image, Fisher vector encoding method is used to analyze the texture feat...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Cheng Luo1†, Xiqing Bian1†, Qian Zhang2, Zhenyan Xia1, Bowen Liu1, Qi Chen1, Chienchih Ke3,4, Jian-Lin Wu1* and Yonghua Zhao5* 1State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China 2Department of Biotherapy, Shenzhen Luohu People’s Hospital, Shenzhen, China 3Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 4Biomedical Imaging Research Center, National Yang-Ming University, Taipei, Taiwan 5State Key Laboratory of Quality Research in Chinese Medi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study reports on four histological biomarkers, gliosis, immune infiltrate, hemorrhage, necrosis, and their prognostic significance in BCBM.MethodsA biobank of 203 human tissues from patients who underwent craniotomy for BCBM was created across four academic institutions. Degree of gliosis, immune infiltrate, hemorrhage, and necrosis were identified and scored via representative H&E stain (0 –3+). Overall survival (OS) was estimated using the Kaplan–Meier method. Cox proportional hazards regression evaluated prognostic value of the biomarkers in the context of standard clinical characteristics.ResultsBCBM s...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
(Far Eastern Federal University) Scientists from Far Eastern Federal University (FEFU) in cooperation with colleagues from Blokhin Russian Cancer Research Center (Moscow), Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors. Researchers revealed a number of proteins, which are potential targets to attack during complex antitumor therapy. A related article was published in Oncology Reports.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma. Oncol Rep. 2019 Apr 16;: Authors: Yu D, Zhao J, Wang Y, Hu J, Zhao Q, Li J, Zhu J Abstract Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it is involved in the regulation of the release of various neurotransmitters in the brain. Recent studies have demonstrated that the expression of HRH3 is upregulated in several types of cancer. However, the functional effect of HRH3 on tumor progression remains largely unknown, particularly in hepatocellular carcinoma (HCC)....
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the expression of genes and the activity of glycolytic enzymes, metalloenzymes, hormones, proteins, neuropeptides and cytokine...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Survivals of advanced anaplastic lymphoma kinase (ALK –positive) non-small cell lung cancer (NSCLC) patients have dramatically changed since the development of efficient ALK tyrosine kinase inhibitors (TKi). However, ALK-positive patients seem to relapse more commonly in the central nervous system (CNS), considered as a sanctuary site. Whether brain metastases (BM) or lepto-meningeal disease (LMD), both are associated with very poor prognosis [1]. Though there is evidence of intracranial activity of 1st generation ALK TKi - crizontib to 2nd and next-generations TKi alectinib, ceretinib against BM, few cases report their activity on LMD.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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