Twin sisters, 32, diagnosed with breast cancer just three months apart

Ashley Huffman, 32, from Michigan, was diagnosed with breast cancer in November 2018. Her twin sister, Danielle Jones, was diagnosed just three months later in February 2019.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In this study we investigated whether other miR-96 regulated genes can enhance ABCE1's anti-cancer effects. We identified one such gene - LCP1 - and proved its negative effect on breast cancer progression. Interestingly, dual inhibition of ABCE1 and LCP1 resulted in an additive effect on cancer cell migration, invasion, and proliferation. Furthermore, in vivo analysis of dual ABCE1 and LCP1 knockdown resulted in significant tumor growth inhibition, decreased metastatic activity, and contributed to survival compared to either gene, separately. This indicates that the combined downregulation of two miR-96 gene targets has an...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β. Oncotarget. 2019 Mar 12;10(21):2068-2085 Authors: Tawara K, Scott H, Emathinger J, Wolf C, LaJoie D, Hedeen D, Bond L, Montgomery P, Jorcyk C Abstract Chronic inflammation has been recognized as a risk factor for the development and maintenance of malignant disease. Cytokines such as interleukin-6 (IL-6), oncostatin M (OSM), and interleukin-1 beta (IL-1β) promote the development of both acute and chronic inflammation while promoting in vitro metrics o...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Goyette MA, Cusseddu R, Elkholi I, Abu-Thuraia A, El-Hachem N, Haibe-Kains B, Gratton JP, Côté JF Abstract Triple-Negative Breast Cancer (TNBC) is an aggressive cancer subtype that is associated with a poor prognosis due to its propensity to form metastases. The receptor tyrosine kinase AXL plays a role in tumor cell dissemination and its expression in breast cancers correlates with poor patient survival. Here, we explored whether already used drugs might elicit a gene signature similar to that seen with AXL knockdown in TNBC cells and which could, therefore, offer an opportunity for drug repu...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We describe the guideline-based decision support system (GL-DSS) of the project. Various breast cancer clinical practice guidelines (CPGs) have been selected to be concurrently applied to provide state-of-the-art patient-specific recommendations. The aim is to reconcile CPG recommendations with the objective of complementarity to enlarge the number of clinical situations covered by the GL-DSS. Input and output data exchange with the GL-DSS is performed using FHIR. We used a knowledge model of the domain as an ontology on which relies the reasoning process performed by rules that encode the selected CPGs. Semantic web tools...
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research
Publication date: Available online 22 April 2019Source: Pathology - Research and PracticeAuthor(s): Guomin Xiang, Fang Liu, Jing Liu, Qingxiang Meng, Nannan Li, Yun NiuAbstractBackgroundIn androgen-sensitive prostate cancer, androgenic stimulation induces the synthesis of amphiregulin (AREG). Research is lacking on the role of AREG in invasive breast cancer and the co-expression with androgen receptor (AR) status.MATERIALS AND METHODS: The present study investigated the prognostic role of AREG in invasive breast cancer cases (N = 298) and the co-expression with the AR status as analysed by immunohistochemistr...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conditions:   Breast Cancer;   Bone Metastases Intervention:   Diagnostic Test: Intensive screening / routine screening Sponsors:   Peking University People's Hospital;   Fudan University;   Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University;   Sun Yat-sen University;   Harbin Medical University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Radiodermatitis;   Breast Cancer Interventions:   Device: Photobiomodulation therapy (PBMT);   Device: Sham laser Sponsors:   Hasselt University;   Jessa Hospital;   Ziekenhuis Oost-Limburg Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
My husband recently planned a beautiful evening for me at our favorite restaurant, complete with a night away at a boutique hotel in wine country, in honor of my “cancerversary,” which for me marked one year since being diagnosed with breast cancer at age 37. It really felt very celebratory, filled with champagne toasts and […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs
ConclusionALU species 115 and 247 levels in serum were elevated in breast and prostate cancer patients compared to their counterpart healthy controls. DNA integrity was higher in prostate cancer patients than the control but in breast cancer patients was lower compared to their controls. In prostate but not in breast cancers, DNA integrity increased with disease severity and higher staging.
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Breast MRI is the most sensitive tool for detecting breast cancer, but its...Read more on AuntMinnie.comRelated Reading: Evidence-based medicine 'misused' in breast MRI Short breast MRI protocol works for cancer detection Breast MRI benefits women across all risk categories Short is just as sweet for breast MRI protocol ASCO BCS: Breast MRI useful for average-risk women, too
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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