Five-month-old boy dies days after hopes of a life-saving liver transplant fell through

Marcus Albers, five months, from Waukesha, Wisconsin, was born with an extremely rare genetic disease known as Immunodeficiency 47. He passed away on April 10 in need of a liver transplant.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Hospitals and patients are suing to block a new nationwide liver transplant policy that they say will waste viable livers, lead to fewer transplants and likely cause deaths
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Conclusion In conclusion, this study wants to stress the importance of early diagnosis. As in the majority of primary immunodeficiency diseases, the prognosis of LAD3 is extremely dependent on early age diagnosis, with timely management of bacterial infections and consideration for HSCT. In addition, this autosomal recessive disorder has high incidence in areas with high rate of consanguineous marriages. Therefore, broadening the spectrum of known mutations underlying the phenotype of such a life-threatening disease can help offering and performing better genetic counseling and prenatal diagnosis. Ethics Statement This ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Geng-Hong Xia1†, Chao You1,2†, Xu-Xuan Gao1, Xiu-Li Zeng1, Jia-Jia Zhu1, Kai-Yu Xu3, Chu-Hong Tan1, Ruo-Ting Xu1, Qi-Heng Wu1, Hong-Wei Zhou3, Yan He4*‡ and Jia Yin1*‡ 1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China 2Department of Neurology, The First People's Hospital of Zunyi, Zunyi, China 3State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China 4Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical Univ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Guidelines to evaluate patients for coronary artery disease (CAD) during pre-operative evaluation for orthotopic liver transplantation (OLT) are conflicting. Cardiac catheterization is not without risk in patients with end-stage liver disease. No study to date has looked at the utility of non-electrocardiogram (ECG)-gated chest computed tomography (CT) in the pre-liver transplant population. Our hypothesis was that coronary artery calcium scores (CACS) from chest CT scans ordered during the liver transplant workup, can identify patients who would benefit from invasive angiography.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the pathogenesis of fatty liver diseases. Necroptosis is regulated by three key proteins: receptor-interacting serine/threonine kinase 1 (RIP1; official name RIPK1), RIP3, and mixed lineage kinase like protein (MLKL). Here, we found that western diet (WD) induced marked steatosis in mouse livers, which was associated with the inhibition of hepatic proteasome activities and increased levels of key necroptosis proteins.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
Infections with zoonotic hepatitis E virus (HEV) have been increasingly reported in industrialized countries. Three months of detectable virus replication define chronic HEV infection,1 which may rapidly progress to severe liver disease.2 Patients under immunosuppression following solid organ transplantation represent the largest group at risk of chronic HEV infection. However, there have been anecdotal reports about chronic HEV infection in patients receiving immunosuppressive medication regimens including rituximab or inhibitors of TNF- α.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Researchers from Saudi Arabia have created 3D-printed models based on the CT...Read more on AuntMinnie.comRelated Reading: 3D printing reduces liver transplant costs, surgery time 3D printing yields custom-fit glasses for kids 3D printing helps separate rare case of conjoined twins 3D printing gives pediatric heart surgery a boost 3D-printed lungs improve patient understanding of surgery
Source: Headlines - Category: Radiology Source Type: news
Conclusions: Despite studies showing that patient portals have the potential to benefit transplant recipients as a tool for health management, racial and socioeconomic disparities should be considered before widespread implementation. Transplant centers should include portal training and support to all patients to encourage use, given its potential to improve outcomes.
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
Authors: Tokodai K, Karadagi A, Kjaernet F, Romano A, Ericzon BG, Nowak G Abstract OBJECTIVES: Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS: We retrospectively examined 95 patients who had undergone LT for NASH or alcoholic liver disease (ALD) as a primary indication. We evaluated peritransplant characteristics and histological findings 1-year post LT amon...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
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