Brain Network and Abnormal Hemispheric Asymmetry Analyses to Explore the Marginal Differences in Glucose Metabolic Distributions Among Alzheimer's Disease, Parkinson's Disease Dementia, and Lewy Body Dementia

This study therefore recruited patients with AD, PDD, and DLB, in comparison with HC, with two main objectives: (1) exploration of the disrupted glucose metabolism network topology (brain network) and comparison of related parameters, and (2) exploration of hemispheric asymmetry. Materials and Methods Participants Metabolic brain images were acquired using 18F-labeled fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) from four groups, including 22 healthy subjects, and 22, 18, and 22 patients with AD, PDD, and DLB, respectively. Subjects were recruited from the PET Center of Huashan Hospital, Shanghai, China. All participants were right-handed. Three days before and after PET image acquisition, we obtained basic information about these subjects, including their age, sex, and Mini-Mental State Examination (MMSE) scores (Table 1). All aspects of the study were approved by the Human Studies Institutional Review Board, Huashan Hospital. TABLE 1 Table 1. Statistical information from all participants. PET Image Acquisition and Preprocessing Whole brain PET images were acquired from 84 participants using a Siemens Biograph 64 PET/CT machine in the PET Center of Huashan Hospital in Shanghai, China. The spatial resolution of the PET scanner was 5.9 mm full-width at half-maximum (FWHM) in the transaxial plane and 5.5 mm FWHM in the axial plane. All subjects were intravenously injected with 185 MBq FDG in a dimly-lit, quiet room. They were asked to keep ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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ConclusionsThese results demonstrate that a novel proton-coupled organic cation antiporter plays a predominant role in the blood to brain influx of AC, MA and HA at the BBB, and thus affect the safety of Aconitum species.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study investigated the cardioprotective effect of vitexin against MIRI and its possible mechanism. Isolated SD rat hearts were subjected to MIRI in a Langendorff perfusion system, and H9c2 cells were subjected to hypoxia/reoxygenation (H/R) in vitro. Ex vivo experiments showed improved left ventricular function and reduced infarct size in the vitexin group. Transmission electron microscopy showed that I/R caused outer mitochondrial membrane rupture, cristae disappearance and vacuolation, while vitexin reduced mitochondrial damage and ultimately reduced cardiomyocyte apoptosis. In vitro, vitexin protected H9c2 cells fr...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Barton BB, Segger F, Fischer K, Obermeier M, Musil R Abstract Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyses mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder).Areas covered: Pub Med and Web of Science were systemat...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Publication date: Available online 20 January 2020Source: Materials Science and Engineering: AAuthor(s): K. Korgiopoulos, M. PekguleryuzAbstractIt was observed that low level of yttrium (Y) has a modifying effect on the Mg17Al12 phase in the binary Mg-6wt%Al casting alloy. Scanning/transmission electron microscopy, mechanical testing and thermodynamic calculations were employed to understand the modification mechanism. It is found that Y at trace level refines the β-Mg17Al12 phase leading to increased tensile elongation and compressive strain to fracture. The refinement effect is lost with further increase in the Y le...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: Available online 20 January 2020Source: Clinica Chimica ActaAuthor(s): Hanna AntushevichAbstractFecal microbiota transplantation (FMT) is the introduction (transplantation) of gut microbiota obtained from the faeces of a healthy donor into the patient’s gastrointestinal tract. Most often, such therapy is used the treatment of gastrointestinal diseases caused by the activity of pathogenic or conditionally pathogenic microorganisms, however, recently an increasing number of studies have reported the use of fecal microbiota transplantation for the treatment of diseases such as metabolic syndrome, diabe...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
This article includes references to self-injury, intravenous drug use and disordered eating.* One in five US high school students have reported being bullied. Approximately 160,000 teenagers have skipped school as a preventative measure. I encountered bullies for the first time in second grade, in the midst of such an innocent time of my youth. I dreaded entering my elementary school classroom, as I was well aware of what my presence would entail. I endured both verbal and physical harassment from my fellow peers for nearly a decade. I was passive, inevitably leading to the acceptance of my “fate,” in addition ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Anorexia Bullying Depression Eating Disorders Personal Stories Substance Abuse Addiction Recovery Anorexia Nervosa Drug Use heroin Self Harm Self Injury Source Type: news
Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Publication date: Available online 20 January 2020Source: Food HydrocolloidsAuthor(s): Yuying Wang, Anqi Zhang, Xibo Wang, Ning Xu, Lianzhou JiangAbstractFor the first time, the irradiation technology combined with Maillard reaction were used to improve the freeze - thaw stability of soybean protein emulsion. The freeze-thaw stability of emulsions prepared with soy protein isolate (SPI), soy protein isolate and maltose mixture (SPI+M) or glycosylated soy protein isolate with maltose formed by irradiation of 7.5 kGy and 12.5 kGy (named SPI-M7.5 and SPI-M12.5, respectively) was compared. Fourier transform infrared spectrosco...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
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