Brain Network and Abnormal Hemispheric Asymmetry Analyses to Explore the Marginal Differences in Glucose Metabolic Distributions Among Alzheimer's Disease, Parkinson's Disease Dementia, and Lewy Body Dementia
This study therefore recruited patients with AD, PDD, and DLB, in comparison with HC, with two main objectives: (1) exploration of the disrupted glucose metabolism network topology (brain network) and comparison of related parameters, and (2) exploration of hemispheric asymmetry.
Materials and Methods
Participants
Metabolic brain images were acquired using 18F-labeled fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) from four groups, including 22 healthy subjects, and 22, 18, and 22 patients with AD, PDD, and DLB, respectively. Subjects were recruited from the PET Center of Huashan Hospital, Shanghai, China. All participants were right-handed. Three days before and after PET image acquisition, we obtained basic information about these subjects, including their age, sex, and Mini-Mental State Examination (MMSE) scores (Table 1). All aspects of the study were approved by the Human Studies Institutional Review Board, Huashan Hospital.
TABLE 1
Table 1. Statistical information from all participants.
PET Image Acquisition and Preprocessing
Whole brain PET images were acquired from 84 participants using a Siemens Biograph 64 PET/CT machine in the PET Center of Huashan Hospital in Shanghai, China. The spatial resolution of the PET scanner was 5.9 mm full-width at half-maximum (FWHM) in the transaxial plane and 5.5 mm FWHM in the axial plane. All subjects were intravenously injected with 185 MBq FDG in a dimly-lit, quiet room. They were asked to keep ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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