Itchy Skin Common Alongside Kidney Disease

THURSDAY, April 11, 2019 -- Itchy skin can make you miserable. And it's a common problem for many people with chronic kidney disease, even those not on dialysis, a new study finds. " One of the main goals of managing chronic disease is alleviating...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Conclusion: Better skin management is needed for itch in patients with ESRD or CKD. Moisturizing and lifestyle factors are important. Topical or oral medications may also be used. Nalfurafine, a κ receptor agonist, is now available in Japan for the treatment of uremic pruritus in these patients.Blood Purif 2019;47(suppl 2):1 –5
Source: Blood Purification - Category: Hematology Source Type: research
AbstractChloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever. This acute itching (2 –7 days duration) exhibits age dependency and a racial and genetic predilection. CQ itch is nonā€histaminergic, which makes it both a good model and a tool to probe the mechanisms of chronic itch. This review focuses on recently discovered mechanisms, neuroscience, mediators, and receptors that are implicated in molecular studies of CQ pruritus. CQ pruritus mechanisms are also compared to that of itching following other systemic diseases, such as chronic kidney disease, chron...
Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Review Source Type: research
Conclusion: Improvement of sleep quality and quality of life among patients with CKD-associated pruritus requires great importance. This study aims to improve the quality of sleep and quality of life among patients with hemodialysis suffering from CKD-associated pruritus.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
End-stage renal disease chronic itch is a frequent symptom that bothers patients with advanced stages of chronic kidney disease. The pathogenesis of the chronic itch symptom is complex and not yet fully understood and includes many metabolic, immunologic, and neurogenic factors. A significant burden of the disease results in decreased quality of life with sleep impairment, depressive symptoms, and increased mortality of affected individuals. No treatment of choice is available; topical therapy (emollients), phototherapy (UV-B), and systemic therapy (antiepileptics, opioid agonists, and antagonists) provide significant reli...
Source: Dermatologic Clinics - Category: Dermatology Authors: Source Type: research
Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
The objective of this study was to evaluate scientific evidence in psychotropic use in the treatment of itch of various causes. This is a systematic review of scientific literature. The following databases were used: PubMed, Web of Science, Scopus and Scielo. Randomized controlled trials that should focus on treatment with psychotropic drugs of pruritus of various causes were the inclusion criteria. All articles were analyzed by the authors, and the consensus was reached in cases of disagreement. Fifteen articles were included after analysis and selection in databases, with the majority of clinical trials focusing on psych...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
A 42-year-old woman with history of IgA nephropathy with chronic kidney disease, Stage 5 and hypertension presented with poor appetite, generalized itchy and dysgeusia with decreasing sensation to salt. She denied smoking and betel nuts use. Extra-oral examination revealed petechiae on her back and subconjunctival hemorrhage on her left eye. Intraoral examination revealed the presence of white plaques predominantly involving the lateral borders and dorsal surface of the tongue (Figure 1a), floor of the mouth and buccal mucosae (Figure 1b). The results of blood tests were as follows: white blood cell count of 6.62 × 1...
Source: QJM - Category: Internal Medicine Source Type: research
Publication date: Available online 23 November 2016 Source:The Lancet Author(s): Angela C Webster, Evi V Nagler, Rachael L Morton, Philip Masson The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m2, or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also in man...
Source: The Lancet - Category: Journals (General) Source Type: research
Authors: Kremer AE, Mettang T Abstract Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching may cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scaring. The most common internal medicine causes for chronic pruritus are chronic kidney disease, hepatobiliary and hematological disorders as well as adverse drug reactions. Pruritus is less commonly seen in patients with endocrine or metabolic diseases, malabsorptio...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
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