The immunological response to traumatic brain injury

Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the developed world. The accuracy of early outcome-prediction remains poor even when all known prognostic factors are considered, suggesting important currently unidentified variables. In addition, whilst survival and neurological outcomes have improved markedly with the utilisation of therapies that optimise physiology, no treatments specifically modulate the underlying pathophysiology. The immunological response to TBI represents both a potential contributor to outcome heterogeneity and a therapeutically tractable component of the acute disease process.

Source: Journal of Neuroimmunology - April 10, 2019 Category: Allergy & Immunology Authors: E.J. Needham, A. Helmy, E.R. Zanier, J.L. Jones, A.J. Coles, D.K. Menon Tags: Review Article Source Type: research