HAMPT, A Novel Quadruple Drug Combination Designed for Cancer Metastatic Chemoprevention: From Hypothesis to Proof-of-concept.

CONCLUSION: The present study demonstrated that HAMPT is a novel quadruple drug combination that can safely and effectively prevent cancer metastasis. PMID: 30968769 [PubMed - in process]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research

Related Links:

Abstract Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease that is characterized by primary ciliary dysfunction (ciliopathy) and progresses to end-stage kidney disease (ESKD) during the second decade of life (juvenile and adolescent NPHP) or before the age of 3 years (infantile NPHP). Here we describe the case of an infant with NPHP who carries a homozygous mutation in SDCCAG8 (also called NPHP10 or BBS16) that encodes SDCCAG8 (serologically defined colon cancer antigen 8). SDCCAG8 is localized at the centrioles of both renal epithelial cells and retinal photoreceptor cells. A mutation in SDC...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Conclusion: Appropriate vitamin D levels were shown to be important in preventing the onset of CRC. PMID: 31534963 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study evaluated the effectiveness of the Caribe Colon inflatable colon model in two community events as an educational tool to increase CRC knowledge, awareness, and intention to undergo CRC screening. METHODS: Participants (aged ≥ 40 years and with no previous CRC history) completed a pre- and post- questionnaire, and took the tour of the Caribe Colon. RESULTS: After completing the tour, survey responses (n=154) revealed a significant increase in CRC knowledge and awareness (p
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Publication date: Available online 19 September 2019Source: Journal of Molecular StructureAuthor(s): Srikanth Gatadi, Gauthami Pulivendala, Jitendra Gour, Satyaveni Malasala, Sushmitha Bujji, Ramulu Parupalli, Mujahid Shaikh, Chandraiah Godugu, Srinivas NanduriAbstractA series of new 4(3H)-quinazolinones were synthesized and evaluated for their cytotoxic activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 and HT-29 (colon) and A549 (lung). Among the tested compounds, 22a exhibited promising cytotoxic activity against MDA-MB-231 (IC50: 3.21μM) and HT-29 (IC50: 7.23 μM) cell lines. ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
No abstract available
Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research
CONCLUSION: Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas. PMID: 31528248 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Recurrence and metastasis are the primary causes of mortality in patients with colorectal cancer (CRC), and therefore effective tools to reduce morbidity and mortality of CRC patients are necessary. LOX-1, the ox-LDL receptor, is strongly involved in inflammation, obesity, and atherosclerosis, and several studies have assessed its role in the carcinogenesis process linking ROS, metabolic disorders and cancer. We have already demonstrated in vitro that LOX-1 expression correlates to the aggressiveness of human colon cancer and its downregulation weakens the tumoral phenotype, indicating its potential function as a biomarker...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study aims to investigate the antiproliferative activity and potential mechanism of action of the xanthoquinodin JBIR-99, isolated from fungi Parengyodontium album MEXU 30,054 and identified by single-crystal X-ray crystallography. Cytotoxicity of xanthoquinodin was evaluated in a panel of human cancer cells lines and CCD-112-CoN normal colon cells, using the sulforhodamine B assay. PC-3 prostate cancer cells were used in biochemical assays including cell cycle, mitochondrial transmembrane potential (MTP), reactive oxygen species (ROS) and caspase activity. Expression levels of apoptosis-pathway-related proteins were ...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Conclusions: The results suggest that these polymorphisms probably has not a substantial role in Iranian CRC risk and is not a serious potential factor in risk assessment of mentioned disease among Iranians. PMID: 31523666 [PubMed]
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
Colorectal cancer (cancer that starts in the colon or rectum) is the third most commonly diagnosed cancer and the second leading cause of cancer death in the United States. There is a significant unmet need for improved therapies against this deadly disease – despite early detection increasing survival rates. Mouse models resembling the biological situation are necessary in the evaluation of chemotherapeutic or immunotherapeutic agents against colon cancer. The murine colon adenocarcinoma cell line, MC-38, was used to create the MC-38 cell line-derived xenograft model, which is widely used to study the prolifera...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
More News: Aspirin | Cancer | Cancer & Oncology | Colon Cancer | Colorectal Cancer | Doxycycline | Science | Study