Immunogenicity analysis of genetically conserved segments in Plasmodium ovale merozoite surface protein-8

Plasmodium ovale is widely distributed across tropical regions and has two closely related but distinct species, namely P. ovale curtisi and P. ovale wallikeri. Combining genetic characterization with the immunog...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

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Induction of memory CD8+ T cells is important for controlling infections such as malaria and HIV/AIDS and for cancer immunotherapy. Accurate assessment of antigen-specific (Ag-specific) CD8+ T cells is critical for vaccine optimization and for defining correlates of protection. However, conditions for determining Ag-specific CD8+ T cell responses ex vivo using intracellular cytokine staining (ICS) may be variable, especially in humans with complex antigens. Here, we used an attenuated whole parasite malaria vaccine model in humans and various experimental infections in mice to show that the duration of antigenic stimulatio...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
by Luis Miguel Gonz ález, Karel Estrada, Ricardo Grande, Verónica Jiménez-Jacinto, Leticia Vega-Alvarado, Elena Sevilla, Jorge de la Barrera, Isabel Cuesta, Ángel Zaballos, José Manuel Bautista, Cheryl A. Lobo, Alejandro Sánchez-Flores, Estrella Montero Babesiosis is considered an emerging disease because its incidence has significantly increased in the last 30 years, providing evidence of the expanding range of this rare but potentially life-threatening zoonotic disease.Babesia divergens is a causative agent of babesiosis in humans and cattle in Europe. The recently sequenced gen...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Dennis J. Grab, Olga V. Nikolskaia, Bertrand Courtioux, Oriel M. M. Thekisoe, Stefan Magez, Maxim Bogorad, J. Stephen Dumler, Sylvie Bisser ObjectiveWhere human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections byTrypanosoma brucei gambiense in blood smears and/or cerebrospinal fluid (CSF) in the critical early stages of the disease is the single most important factor in treatment failure, a result of delayed treatment onset or its absence. We hypothesized that the enhanced sensitivity of detergent-enhanced loop-mediated isothermal amplification (LAMP) will allow for point o...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This week's case was donated by Florida Fan and one of his coworkers who found this beauty in some fresh salmon:Posterior end: Anterior end:Identification?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Publication date: Available online 17 August 2019Source: Small Ruminant ResearchAuthor(s): B. Lambacher, C.M. Frei, J. Schoiswohl, A. Tichy, J. Elmer, J. Frei, R. Krametter-FrötscherAbstractDue to the growing importance of endoparasitoses in Austrian lambs this study evaluated the prevalence of gastrointestinal strongylids (GIS) in 221 lambs at slaughter, focusing on the prevalence of Haemonchus contortus. The study also assessed associations between clinical signs, adult infestation of the abomasa and faecal excretion of strongylid eggs. From faecal examinations, 65.6% of lambs were positive for strongylids. Larval c...
Source: Small Ruminant Research - Category: Zoology Source Type: research
In this study, 13-15-months-old Holstein-Friesian steers were immunised with a subunit vaccine as a prime and a modified vaccinia Ankara vector as a boost, both expressing a chimeric multi-antigen (rMABbo – rMVA). This antigen includes the immunodominant B and T cell epitopes of three B. bovis proteins: merozoite surface antigen - 2c (MSA - 2c), rhoptry associated protein 1 (RAP - 1) and heat shock protein 20 (HSP20). Responses were compared with the Babesia bovis live attenuated vaccine used in Argentina (R1A). Eleven weeks after the first immunisation, all bovines were challenged by the inoculation of a virulent B....
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In conclusion, it is recommended that in addition to direct microscopic examination, the use of additional methods such as culture and PCR will be useful in routine laboratory diagnosis of Blastocystis spp. The distribution of Blastocystis subtype in Aydin is mainly in accordance with the global findings. Lack of a relationship between Blastocystis spp. İnfection and symptoms in our study was supported the idea that Blastocystis spp. infection is mostly asymptomatic in humans and it may be a member of healthy microbiota. PMID: 31414632 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Publication date: Available online 16 August 2019Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Lana Harriott, Matthew Gentle, Rebecca Traub, Rowland Cobbold, Ricardo Soares MagalhãesAbstractThe transmission of zoonotic pathogens associated with wildlife in peri-urban environments can be influenced by the interplay of numerous socioecological factors. Echinococcus granulosus is known to be common within peri-urban wild dog populations however knowledge of the factors that influence its presence is limited. We investigated the demographic distribution of the Index of Potential Contam...
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
Publication date: Available online 16 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Ilaria Pascucci, Marco Di Domenico, Giulia Capobianco Dondona, Annapia Di Gennaro, Andrea Polci, Andrea Capobianco Dondona, Elisa Mancuso, Cesare Cammà, Giovanni Savini, Jacopo G. Cecere, Fernando Spina, Federica MonacoAbstractThe continuous flow of billions of birds between Africa and Europe creates an “ecological bridge” between physically remote areas. Migratory birds fly south from their breeding grounds during late summer/fall and fly back in spring. These movements regulate the spread of internal and ex...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 15 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Jiří Černý, Buyantogtokh Buyannemekh, Tersia Needham, Gantulga Gankhuyag, Dashzeveg OyuntsetsegAbstractTicks and tick-borne pathogens (TBPs) pose a considerable threat to human and animal health in Mongolia; a large and sparsely inhabited country whose economy is largely dependent on animal production. Intensive contact between herdsmen and their livestock, together with the use of pastures without fencing, allows contact between wildlife, domestic animals and humans, thus creating ideal conditions for epizoonos...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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