Passive, Active and Ultrasonic Drug Delivery.

Passive, Active and Ultrasonic Drug Delivery. Mini Rev Med Chem. 2019 Apr 08;: Authors: Basha SA, Dalibalta S, Husseini GA Abstract Cancer has become one of the most deadly non-communicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy and low side effects. The most common example of such modalities is the use chemotherapeutic drugs to destroy cancerous cells and deter their uncontrolled proliferation. Parallel to the destruction of cancerous tissue; chemotherapy destroys normal, healthy tissues, as it lacks the specificity to annihilate cancerous cells preferentially resulting in adverse side effects that include nausea, hair fall, and cardiac infarction. To prevent the unwanted and toxic side effects of non-selective chemotherapy, cancer therapy research has been focused on the implementation of nanocarrier systems that act as vehicles to encapsulate the drug and selectively transport this agent to the tumor site. After describing the nature of nanoparticles, specifically liposomes, this paper sheds light on the combination of three anticancer drug delivery approaches; passive, active and ultrasound-triggered targeting drug delivery. It also highlights other uses of liposomes as drug-carrying vehicles, including their utilization in boron neutron capture therapy. PMID: 30961495 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research