Electrochemical simultaneous analysis of dopamine and epinephrine using double imprinted One MoNomer acryloylated graphene oxide-carbon black composite polymer

Publication date: Available online 11 April 2019Source: Biosensors and BioelectronicsAuthor(s): Sana Fatma, Bhim Bali Prasad, Swadha Jaiswal, Richa Singh, Kislay SinghAbstractA novel One MoNomer dual imprinted graphene oxide/carbon black composite polymer was developed applying ‘surface-grafting from’ approach on the screen printed carbon electrode for the electrochemical sensing of dopamine and epinephrine. Acryloylated-graphene oxide/carbon black was synthesized for the first time. This served both as a crosslinker and monomer leading to the fast electron transfer from the redox centre to the electrode. The oxidation peak potentials of both the targets were found separated by 200 mV which enabled their simultaneous analysis in real world samples, without any cross reactivity, interferences, and false-positives. The detection limits realized by the proposed sensor, under optimized analytical conditions, were found to be as low as 0.028, 0.028,0.061 and 0.029 ng mL−1 for dopamine and 0.017, 0.018, 0.019 and 0.020 ng mL−1 for epinephrine (S/N = 3) in aqueous, blood serum, urine and pharmaceutical samples. Such sensor could be considered suitable for the primitive diagnosis of several chronic diseases, manifested at ultra-trace level.

Source: Biosensors and Bioelectronics - April 11, 2019 Category: Biotechnology Source Type: research