Synthesis and biological evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole derivatives as xanthine oxidase inhibitors.
CONCLUSION: Compound 1h could be a lead compound for further investigation and the present work may provide some insight into the search for more structurally diverse XO inhibitors with topiroxostat as a prototype.
PMID: 30963981 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Li SY, Zhang TJ, Wu QX, Mohamed OK, Zhang Y, Meng FH Tags: Med Chem Source Type: research