Preparation of Balangu (Lallemantia royleana) seed mucilage aerogels loaded with paracetamol: evaluation of drug loading via response surface methodology

Publication date: Available online 11 April 2019Source: The Journal of Supercritical FluidsAuthor(s): Mohammad Taghi Falahati, Seyyed M. GhoreishiAbstractIn this work, paracetamol (PCM) loading into Balangu seed mucilage (BSM) aerogels was investigated using the combination of supercritical drying and gas antisolvent (GAS) precipitation method. Response surface methodology (RSM) was implemented for the modeling and optimization of drug loading into the aerogel matrix. The temperature (40-60 °C), pressure (8-24 MPa) and drug solution concentration (0.2-0.6 Molar) were considered as the range of operating variables. The prepared aerogels were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and N2 adsorption-desorption analysis. The optimal operating conditions were determined to be the pressure of 8 MPa, the temperature of 40 °C and the drug solution concentration of 0.2 M in which the maximum drug loading (DL) of 33% was achieved. The RSM verified that R2 and modified R2 of the model were 98.53% and 97.25%, respectively.Graphical abstract

Source: The Journal of Supercritical Fluids - April 11, 2019 Category: Chemistry Source Type: research