Cytotoxic chalcones and isoflavones from the stems of Dalbergia velutina

Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Sutin Kaennakam, Edwin Risky Sukandar, Kitiya Rassamee, Pongpun Siripong, Santi Tip-pyangAbstractFour new compounds, including two new chalcones, veluchalcone A and B (1 and 2), and two new isoflavones, veluisoflavone A and B (3 and 4), together with five known chalcones (5–9) and ten known isoflavones (10–19), were isolated from the stems of Dalbergia velutina. The structures of these compounds were determined by spectroscopic analysis. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, Hep G2 and HT-29). Compounds 7–9 showed significant cytotoxicity against KB, HeLa S-3 and HT-29 cells with IC50 values in the range of 2.42–9.89 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research