Cancer symptoms: The sign in your mouth that could indicate the deadly disease

CANCER symptoms can be subtle and are worryingly often confused with other, less serious conditions. That ’s why it’s important to be aware of any unexplained changes to your body. One symptom of some types of cancer which is not easily recognised, can be detected in the mouth.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 16 April 2019Source: Life SciencesAuthor(s): Sha-sha Wang, Ya-ling Tang, Xin Pang, Min Zheng, Ya-jie Tang, Xin-hua LiangAbstractOral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed th...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionBilateral Fujimori one-stage flaps can be used in cases of squamous cell carcinomas involving most of the lower lip, including the commissures of the mouth. A limitation of the method is an eventual lack of local tissue when preparing the flap.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Munch a bit of habanero pepper or hot-sauce-soaked jambalaya, and you’ll notice a tingling numbness in your mouth followed by a burning sensation. If that burning sensation is sufficiently strong, your nose and eyes will start to run, and your mouth and throat will start to generate mucus. You may not be able to feel it, but your stomach and parts of your intestine will also start secreting excess fluid, says Dr. Brett Comer, a surgeon and ear, nose, and throat specialist at the University of Kentucky College of Medicine. Why does all this happen? Like spraying water on a filthy car, your body turns on the waterworks...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition Source Type: news
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, we show that PD-1 acts to inhibit the effector functions of virus-specific CD8 bTRM during MuPyV encephalitis. NanoString inflammatory gene expression analysis of brains of wild type (WT) and PD-L1−/− mice infected with MuPyV revealed that PD-1 signaling controls the inflammatory response during acute infection. In striking contrast, the absence of PD-1 signaling during persistent infection resulted in lower neuroinflammation than in WT mice. PD-1 was further found to affect the differentiation of virus-specific CD8 bTRM. Together, these findings reveal a complex, dynamic impact of PD-1 on neuroi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Michio Kawano1, Masaya Miyoshi1 and Tadaaki Miyazaki2* 1Milk Science Research Institute, Megmilk Snow Brand Co. Ltd., Saitama, Japan 2Department of Probiotics Immunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan Lactobacillus helveticus SBT2171 (LH2171) has been reported to ameliorate the development of autoimmune diseases, such as collagen-induced arthritis and experimental autoimmune encephalitis in mice and inhibit interleukin (IL)-6 production in antigen-presenting cells in vitro. Regulation of cytokine production by antigen-presenting cells might be critical for the anti-inflamma...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was carried out in accordance with the recommendations of the Case Western Reserve University IACUC committee. The protocol was approved by the Case Western Reserve University IACUC committee. Author Contributions LRD and DW helped design research studies, analyze data and write the manuscript. ZL, RL, and ND conducted experiments, acquired and analyzed data, and assisted with manuscript preparation. LDM conducted experiments and analyzed data. FC assisted with research design. Funding This work was supported by the NIH P30CA043703, K1CA113838, and R01DK081395. Conflict of Interest Statement The authors de...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Ivana Bjelobaba1,2, Marija M. Janjic1,2, Rafael Maso Prévide1, Daniel Abebe1, Marek Kucka1 and Stanko S. Stojilkovic1* 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, United States 2Institute for Biological Research Sinisa Stankovic, University of Belgrade, Belgrade, Serbia Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: TJ-41 does not increase relative dose and completion rate of S-1 significantly. J-41 may reduce toxic effects, but our findings do not support routine use of TJ-41 after gastrectomy. Introduction The standard treatment for advanced gastric cancer is surgical resection with D2 lymphadenectomy followed by adjuvant chemotherapy in Eastern countries, where gastric cancer is common, while perioperative chemotherapy or chemoradiation is preferred in Western countries (1–3). Adjuvant chemotherapy with S-1 for 1 year yields a 5-year survival rate of 72%, reducing the risk of death by 33% compared to surger...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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