FDA Approves New Osteoporosis Treatment
Evenity, an injected therapy, helps build new bone by blocking the effect of a protein called sclerostin. It’s intended for use only in women at high risk off fracture.
DISCUSSION: The review shows a lack of empirical evidence since sufficient empirical findings regarding the appropriateness of physiotherapy care are missing for many of the indications, in particular on physiotherapy in hospitals and rehabilitation facilities. The results of single studies are limited by insufficient assessment of therapeutic needs or the therapy modalities applied. Analyses which encompass multiple settings and/or providers of care have not been conducted in all studies, even though respective approaches would have been suitable. Nevertheless, suggestions for targeted improvement of the appropriateness o...
This study may provide new clinical management strategy for GIOP cases.
CONCLUSION: This study finds that yoga and meditation are used by middle-to-higher aged Australian women with chronic illnesses. The lack of communication with health care providers is concerning and might hinder coordinated and effective health care around chronic illness. Further research is necessary to help understand possible concurrent health care use and thereby help inform safe, effective and coordinate health seeking amongst those with chronic illness. PMID: 31003661 [PubMed - in process]
ConclusionThis study to our knowledge represents the longest continuous observational period providing data on denosumab persistence in a real-world setting. The total persistence noted is quite robust when compared to bisphosphonates and is within the upper range of prior published studies of denosumab with shorter observation periods.
Osteoporosis, known as the most prevalent bone disorder in the world, is characterized by low bone mass, microarchitectural deterioration of bone tissue and decreased bone strength . An imbalance in bone homeostasis, either from an increase in bone resorption and/or a decrease in bone formation results in bone loss , which increases the risk of fracture with an inevitable increased financial burden for healthcare systems . Based on 2000 census data, the prevalence of osteoporosis is estimated to increase from ∼10 million to>14 million people in 2020 in the United States .
Publication date: Available online 19 April 2019Source: Journal of Theoretical BiologyAuthor(s): Silvia Trichilo, Stefan Scheiner, Mark Forwood, David M.L. Cooper, Peter PivonkaAbstractThis paper presents a pharmacokinetic/pharmacodynamic (PK/PD) model of the action of PTH(1-34) on bone modelling and remodelling, developed for quantitatively investigating the dose- and administration pattern-dependency of the bone tissue response to this drug. Firstly, a PK model of PTH(1-34) was developed, accounting for administration via subcutaneous injections. Subsequently, the PK model was coupled to a (mechanistic) bone cell populat...
Abstract: Estimates indicate 70% of all individuals with HIV will be age 50 or older by 2030. Chronic conditions, including cardiovascular disease, diabetes mellitus, kidney disease, malignancies, neurocognitive disorders, and osteopenia or osteoporosis, occur more frequently in patients with HIV and have become the leading cause of morbidity in this population. NPs play an integral role in helping this population age healthfully.
Conclusions: Once-weekly TPTD administration may facilitate early bony union after acute OVF accompanied by severe osteoporosis. PMID: 31000686 [PubMed - as supplied by publisher]
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Excessive alcohol consumption leads to alcohol use disorder. Alcohol is metabolized to acetaldehyde, which is then oxidized to acetic acid by aldehyde dehydrogenases (ALDH), a class of enzymes that facilitate the conversion of aldehydes to their corresponding acids. Among ALDHs, mitochondrial ALDH2 is the primary enzyme involved in the metabolism of acetaldehyde. In addition to its well-known role in ethanol metabolism, recent studies have suggested that ALDH2 dysfunction is associated with a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, cancer, anemia, pain, osteoporosis and aging.