One in 10 child asthma cases 'linked to traffic pollution'

Current pollution guidelines should be reviewed to improve children's health, a global study says.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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ConclusionThis systematic review highlighted the potential of a goal setting technique in the asthma self-management education. However, due to the limitations of the quality and quantity of the included literature, more rigorous studies are needed. In the future, better effective study protocol combining with goal setting approach and other behavior technique is needed to further investigate.
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
Authors: Nafiu OO, Owusu-Bediako K, Chimbira WT Abstract BACKGROUND: Recent data among pediatric otolaryngology patients showed unexplained higher rates of serious perioperative respiratory adverse events (PRAE) in black children compared to their white peers. We evaluated whether preoperative respiratory comorbidity (PRC) burden contributes to racial disparity in serious PRAE in children undergoing non-otolaryngologic procedures. METHODS: Rates of serious PRAE (laryngospasm and/or bronchospasm) were compared across racial groups in a retrospective cohort of black and white children (N = 18538; black ...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
CONCLUSIONS: Although adults with WRA were more likely to have received asthma self-management education, results suggest missed opportunities to provide asthma self-management education. Every healthcare visit should be used as an opportunity to discuss asthma self-management. PMID: 31001992 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Kang J, Cho YS, Choi DK, Lee JS, Oh YM, Lee SD, Lee SW Abstract Bronchial thermoplasty is a nonpharmacological treatment for severe asthma that delivers thermal energy to the bronchial walls and reduces hypertrophied smooth muscle mass. Previous studies have shown its efficacy and safety, resulting in approval from the Food and Drug Administration in 2010. In Korea, the first bronchial thermoplasty was carried out in 2014; 4 patients have undergone the procedure so far. This case series presents the medical history and treatment outcomes of these 4 patients. All patients presented with uncontrolled asthma ...
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
This study explored the potential association between chronic exposure to pesticide mixtures including paraquat and respiratory outcomes among Colombian farmers. Sociodemographic and occupational data, respiratory symptoms and spirometric data were collected. Paraquat in spot urine samples were quantified with solid-phase extraction high-performance liquid chromatography. Multiple Poisson regressions with robust variance were used to determine factors associated with respiratory outcomes. Profiles of pesticide mixtures used were identified among 217 farmworkers, but profenofos and methamidophos-based mixtures were more fre...
Source: Industrial Health - Category: Occupational Health Tags: Ind Health Source Type: research
Publication date: Available online 20 April 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Milena Vasconcellos Oliveira, Pedro Leme Silva, Patricia Rieken Macedo RoccoMice are frequently used in experimental models of respiratory diseases due to their ease of manipulation, genetic homogeneity within inbred populations, and possibility of standardizing environmental exposures. However, it is well established that genetic strain variations in mice may exist, which imply changes in extracellular matrix (ECM) composition and degree of ECM remodeling, with potential for major impacts on respiratory mechanics. The lu...
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research
CD4+ Foxp3+ regulatory T (Treg) cells represent a subset of CD4+ T cells that function to suppress immune responses mediated by autoreactive or pathogenic effector T (Teff) cells, thus establishing and maintaining tissue immune homeostasis. An imbalance between pathogenic Teff cells and Treg cells results in chronic allergic inflammation, such as asthma and atopic dermatitis (AD). Allergen-specific immunotherapy (ASIT) has been reported to be an effective way to treat AD. Our previous work established a murine model of ASIT and demonstrated clinical and histological improvement, with successful induction of skin Treg cells...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
Autoimmune blistering skin disorders (AIBD) are chronic, debilitating conditions which affect the skin and mucous membranes. Food intolerances have been studied in inflammatory conditions including inflammatory bowel disease, asthma, and cardiovascular disease. Multiple studies have established nutrients ’ ability to alter the microbiota, influence the innate immune system, and modulate inflammation. We sought to assess the role of various food groups in AIBDs. Two hundred patients were surveyed through the International Pemphigus and Pemphigoid Foundation e-mail listserv.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Interventional Studies, Clinical and Patient Outcomes Research Source Type: research
Besides its main clinical in asthma therapy, the phosphodiesterase inhibitor, theophylline, is accepted as a cosmetic agent with potential anti-oxidative and anti-aging properties. However, the effects of theophylline on full-thickness, organ-cultured human skin human skin are poorly explored. Here, we report that theophylline 10 μM and 100μM stimulated expression of the stem cell marker keratin 15 in the epidermis and enhanced the integrity of dermal microfibrils as assessed by fibrillin-1. Theophylline also strongly increased mRNA levels of collagen I and III, decreased MMP2 and MMP9 mRNA levels and up-regulated th...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
The incidence of patients with atopic dermatitis (AD) and respiratory allergic comorbidities, allergic asthma and/or rhinitis, or the so-called allergic march (AM), has been steadily increasing. However, the mechanism underlying the development of AM in patients with AD is unclear. To identify the mechanism, RNA microarray, flow cytometry, quantitative real-time polymerase chain reaction, and immunofluorescence staining were performed using skin, lung tissues, and T-cells from humans and mice with AD and AM compared to AD without AM.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Translational Studies Source Type: research
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