Husband with dementia has finally been able to reconnect with his wife - using a 'Music Memory Box'

The box filled with memorabilia plays songs that are personal to the person with dementia. Steve Garrity, 82, of Bristol, hasn't spoken to his wife, Monica, 74, for five years.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusions: The surrogates were more agreeable to considering assisted dying in the setting of advanced dementia than the physicians, and about half of the participants in both groups reported CDS to be an appropriate option for this population.Neurodegener Dis
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Conclusions: This study represents the first implementation of accessibility settings for dementia in mainstream apps, whilst demonstrating the feasibility and positive impact of the approach. The findings reveal core principles of touchscreen interaction and design for dementia that can inform future app development.Gerontology
Source: Gerontology - Category: Geriatrics Source Type: research
Publication date: 23 April 2019Source: Cell Reports, Volume 27, Issue 4Author(s): Brittany N. Flores, Xingli Li, Ahmed M. Malik, Jose Martinez, Asim A. Beg, Sami J. BarmadaSummaryThe majority of individuals with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) exhibit neuronal cytoplasmic inclusions rich in the RNA binding protein TDP43. Even so, the relation between the RNA binding properties of TDP43 and neurodegeneration remains obscure. Here, we show that engineered mutations disrupting a salt bridge between the RNA recognition motifs of TDP43 interfere with RNA binding and eliminate the recog...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: Available online 24 April 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Yinan Zhao, Yanguo Xin, Su Meng, Zhiyi He, Wenyu HuAbstractThe diagnostic value of neurofilament light chain protein in neurodegenerative dementia diseases is still controversial. A systematic literature search was performed to identify relevant case-control studies conducted through October 2018. Traditional and net meta-analyses were performed based on 42 studies that tested the diagnostic performance of neurofilament light chain protein (NfL) concentration in CSF and serum/plasma from patients with neurodegenerative...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
(Natural News) Many people still use over-the-counter drugs for treating cold symptoms, such as coughing, headaches, muscle pain, and sleeplessness. However, these drugs are known to have harmful side effects. A study published in the journal JAMA Neurology found a link between over-the-counter anticholinergic drugs and cognitive impairment. Anticholinergics are drugs used to treat various conditions, such...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
This study was carried out in accordance with the recommendations of the National Animal Care and Use Committee of the University of Buenos Aires (CICUAL). The protocol was approved by the CICUAL. Mice were kept under a 12-h light/dark cycle, with controlled temperature (23 ± 2°C) and humidity (40–60%) and had ad libitum access to food and water. To produce hTDP-43 transgenic lines, as described previously (Igaz et al., 2011), pronucleus of fertilized eggs from C57BL/6J × C3HeJ F1 matings were injected with a vector containing hTDP-43-WT cDNA. Monogenic tetO-TDP-WT12 mice wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study employed a double-blind, randomized, crossover design, in which 24 healthy right-handed participants conducted MEG recordings during a 3-back task after administration of 2 mA tDCS or sham stimulation as a placebo. Our results showed that the effect of tDCS did not appear in the behavioral indices—WM accuracy (d′) or reaction time (RT). From the results of the time-frequency analysis, significant event-related synchronization (ERS) in the high-gamma band (82–84 Hz) of the left DLPFC was found under the tDCS condition; however, ERS was not correlated with WM capacity. Furthermore, we calculated ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Dear Candid Caregiver: My dad enjoys going to the park and watching kids play. Since I try hard to give him the best life he can have considering that he has Alzheimer’s disease, I find this a positive experience. The problem is that there are times when Dad is glaringly inappropriate and I don’t know how to handle these moments. As an example, last week, he saw a child in the park dipping his toes in a pond. Dad began lecturing the child about not “falling in.” Of course, the child was confused and the mother seemed upset. I explained dad’s situation to the mom and she was kind, but I was emb...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Conclusions: This study improves the knowledge on clinical significance of RBD symptoms in ET patients. Our preliminary findings demonstrate that presence of RBD in ET is associated with neurocognitive impairment, but not with cardiac autonomic dysfunction. Further longitudinal studies are needed to investigate whether ET patients with RBD will develop a frank dementia over the time. Introduction Essential tremor (ET) is one of the most common neurological disease among adults. Traditionally, it is defined by a core of clinical motor symptoms characterized by kinetic/postural tremor affecting hand, head, or other par...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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