Association of BRCA Mutations and Anti-m üllerian Hormone Level in Young Breast Cancer Patients
This study evaluated the association between BRCA mutation status and serum anti-Müllerian hormone (AMH) level in young, reproductive-aged patients with breast cancer. Materials and Methods: Patients ≤ 40 years of age with breast cancer and who had known BRCA status and baseline serum AMH level at Samsung Medical Center, Seoul, Korea, were considered for inclusion. A total of 52 BRCA mutation carriers (27 BRCA1 and 25 BRCA2) and 264 non-carriers were selected for analyses. The serum level of AMH was compared according to presence of a BRCA mutation, and linear and logistic regression analyses were performed to evaluate the association between BRCA mutation and serum AMH level. Results: No difference was found in clinical characteristics between BRCA-mutation carriers and non-carriers. Subjects with any BRCA mutation had a significantly lower median AMH than those without a mutation (2.60 vs. 3.85 ng/mL, 32% reduction, P = 0.004). Linear regression analysis showed a significant negative association between BRCA mutation and AMH level. In addition, logistic regression demonstrated non-significantly increased odds of mutation carriers having AMH
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Publication date: Available online 11 July 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ermira Tartari, Joost Hopman, Benedetta Allegranzi, Bin Gao, Andreas Widmer, Vincent Chi-Chung Cheng, Shuk Ching Wong, Kalisvar Marimuthu, Folasade Ogunsola, Andreas Voss, on behalf of the International Society of Antimicrobial Chemotherapy Infection Prevention Control Working Group, (ISAC-IPC)
Publication date: 30 August 2020Source: International Journal of Pharmaceutics, Volume 586Author(s): Sujuan Zhang, Yongtai Zhang, Zhi Wang, Teng Guo, Xuefeng Hou, Zhiyuan He, Zehui He, Lina Shen, Nianping Feng
Publication date: Available online 10 July 2020Source: Seminars in Cancer BiologyAuthor(s): Ombretta Melaiu, Valeria Lucarini, Roberto Giovannoni, Doriana Fruci, Federica Gemignani
Publication date: Available online 10 July 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yan Zhao, Ya-Ni Zhang, Kai-Ting Wang, Lei Chen
Publication date: Available online 10 July 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Angana Biswas, Yetirajam Rajesh, Pralay Mitra, Mahitosh Mandal
Publication date: December 2020Source: Nano Today, Volume 35Author(s): Ling-xiao Zhang, Xia-mei Sun, Ying-bo Jia, Xiao-ge Liu, Mingdong Dong, Zhi Ping Xu, Rui-tian Liu
, Török P Abstract Introduction: Most endometrial polyps represent focal hyperplasia of the endometrium. Endometrial polyps can be diagnosed by ultrasound, hysterocontrast sonography, hysterosalpingography, endometrial biopsy, and uterine curettage, but diagnostic hysteroscopy is considered the gold-standard method, with the greatest sensitivity and specificity and also with the opportunity for treatment at the same time.Study design: A retrospective study was conducted on 424 patients between 2006 and 2018. The polyps were verified during diagnostic hysteroscopy and were removed by resectoscopy or curet...
é R, Jakab A Abstract Endometrial cancer is the most common gynecological malignancy with a relatively good overall prognosis. It traditionally has two subtypes: type 1 (endometrioid carcinoma) and type 2 (non-endometrioid carcinoma). The prognosis is excellent for stage I endometrioid cancer, with a 5-year survival rate of 96%. However, the prognosis is much worse for women with high-risk endometrial cancer. Effective preoperative staging is important in order to tailor treatment and achieve optimal long-term survival. The majority of asymptomatic polyps detected by ultrasound are treated surgically. Conve...
Abstract Endometrial polyps have a reported prevalence from 7.8% up to 30% and are one of the most cost-consuming gynecological conditions for our specialty. There are strong practitioner beliefs that surgical removal of endometrial polyps is highly beneficial, particularly for those with abnormal uterine bleeding and infertility. Additionally, polypectomy is indicated to reduce the risk of malignancy. Transvaginal ultrasound is the first-line diagnostic option for detection of endometrial polyps, while sonohysterography has similar accuracy as hysteroscopy in the diagnostic confirmation. Blind dilatation and cure...
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