Plasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study

Conclusion: This study observed an inverse correlation between plasma LDL cholesterol and heart function in individuals with T2DM. Patients with higher levels of plasma LDL cholesterol had worse left ventricular function. Therefore, plasma LDL cholesterol may be a modifiable risk factor of heart failure in diabetes, but prospective studies are necessary to confirm this finding. Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease that affects a considerable number of patients worldwide (1). Among diabetic individuals, cardiovascular disease (CVD) is the leading cause of morbidity and mortality (2). Chronic hyperglycemia is associated with vascular dysfunction (3), oxidative stress (4), and proinflammatory cytokines that impair organ function (5). Moreover, patients with T2DM often have concomitant insulin resistance, which aggravates the severity of CVD (6). The sympathoadrenal system has been implicated in the development of insulin resistance, which has detrimental effects on the cardiovascular system (7–9). Insulin resistance in diabetes is related to both glucose intolerance and impaired fatty acid metabolism (10). Indeed, the intimate relationship between fatty acid and glucose in the Randle cycle has strong implications for its role in the development of diabetes (11). Once insulin resistance has developed, it affects heart function through the activation of protein kinase C (12). Overall, hyperglycemia, dyslipidemia, and hypertensive car...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research