Plasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study

Conclusion: This study observed an inverse correlation between plasma LDL cholesterol and heart function in individuals with T2DM. Patients with higher levels of plasma LDL cholesterol had worse left ventricular function. Therefore, plasma LDL cholesterol may be a modifiable risk factor of heart failure in diabetes, but prospective studies are necessary to confirm this finding. Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease that affects a considerable number of patients worldwide (1). Among diabetic individuals, cardiovascular disease (CVD) is the leading cause of morbidity and mortality (2). Chronic hyperglycemia is associated with vascular dysfunction (3), oxidative stress (4), and proinflammatory cytokines that impair organ function (5). Moreover, patients with T2DM often have concomitant insulin resistance, which aggravates the severity of CVD (6). The sympathoadrenal system has been implicated in the development of insulin resistance, which has detrimental effects on the cardiovascular system (7–9). Insulin resistance in diabetes is related to both glucose intolerance and impaired fatty acid metabolism (10). Indeed, the intimate relationship between fatty acid and glucose in the Randle cycle has strong implications for its role in the development of diabetes (11). Once insulin resistance has developed, it affects heart function through the activation of protein kinase C (12). Overall, hyperglycemia, dyslipidemia, and hypertensive cardi...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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ConclusionsThe implication of these results is that policies aimed at reducing inequalities between residential neighborhoods are likely to beneficially affect all racial/ethnic groups but are not sufficient in reducing racial/ethnic disparities in intergenerational transmission of socio-economic status.
Source: Journal of Adolescence - Category: Child Development Source Type: research
Publication date: February 2020Source: Infant Behavior and Development, Volume 58Author(s): Paulo Ricardo H. Rocha, Maria da C.P. Saraiva, Marco A. Barbieri, Alexandre A. Ferraro, Heloisa BettiolAbstractThe present study investigated the association between preterm birth PT conditions, intrauterine growth restriction IUGR and the combination of both PT-IUGR with infant motor development. A cohort with 1006 children was monitored during prenatal, at birth, and two years of age. Bayley-III screening was used to evaluate of fine and gross motor skills. The data did not indicate an increased risk for motor delays in the PT or ...
Source: Infant Behavior and Development - Category: Child Development Source Type: research
This study aimed to investigate the factors affecting the printability and post-processing capacity of cookie dough in extrusion-based 3D printing by modifying the recipe without the addition of gums or stabilizers. Cookie dough formulations with different types of fat (butter and shortening), flour (wheat, rice, and tapioca), the amount of non-fat milk (32.5 or 65 g/100 g flour), and the sugar level (37.5 or 55 g/100 g flour) were investigated for their printability and post-processing capacity. Rheological properties, microstructure, and printability of printing inks were monitored while the moisture loss and dim...
Source: Innovative Food Science and Emerging Technologies - Category: Food Science Source Type: research
This study, from the perspective of “whole food”, aimed to investigate the composition of TFE and further explore its possible health-promoting effects on cyclophosphamide-induced mice. It was found that TFE was mainly composed of carbohydrates (34.02 ± 1.42%), phenolic compounds (11.57 ± 0.14%), crude proteins (27.72 ± 3.07%) and saponins (2.81 ± 0.00%). Supplementation of TFE at 200 mg/kg·BW/d regulated intestinal homeostasis by improving the intestinal barrier, alleviating dysbacteriosis (reverse 44 of 68 disordered genera), stim...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 20 February 2020Source: Food Research InternationalAuthor(s): Zhan Ye, Chen Cao, Qiu Li, Yong-jiang Xu, Yuanfa LiuAbstractPalm oil (PO), leaf lard oil (LO), rapeseed oil (RO), sunflower oil (SO), and linseed oil (LINO) are the five of the most typical dietary lipids, while few studies have explored and compared their influences on the serum lipid profiles, colonic short chain fatty acids (SCFAs) composition and colon health of Sprague Dawley (SD) rats. Results from the present work showed that PO and LO groups showed significantly higher serum TG and TC level compared with Ctrl group, whe...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 18 February 2020Source: Food HydrocolloidsAuthor(s): Xiaqing Wu, Guowen Zhang, Mingming Hu, Junhui Pan, Ang Li, Ying ZhangAbstractAs one of the most reactive dicarbonyl compounds, methylglyoxal (MGO) can react with protein to form advanced glycation end products (AGEs), then promoting the development of diabetic complications. Hence, it is significant for preventing protein glycation mediated by MGO. Here, the anti-glycation potential and mechanism of gallocatechin gallate (GCG) as an active ingredient of green tea were investigated. It was found that GCG exhibit good scavenging activitie...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
In conclusion, unlike traditional alheiras which often contain pathogenic agents, no harmful organisms nor chemical hazards were found in these new products, even though produced by the same companies.
Source: Food Control - Category: Food Science Source Type: research
Conclusion: Antenatal detection of corpus callosum hypoplasia remains challenging. Counseling is difficult because neurodevelopmental outcomes are variable. PMID: 32070177 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
This study aimed to evaluate the effects on lamb meat quality of replacing the soybean meal and corn diet with peanut meal and crude glycerin. A total of 40 lambs, with an initial body weight of 17.15 ± 1.56 kg, were divided into four biodiesel by-product treatment groups: a no-treatment control, peanut meal, crude glycerin, and peanut meal + crude glycerin. The roughage-to-concentrate ratio was 40:60 in all diets. Peanut meal, crude glycerin, and their combination had no effect on the physicochemical characteristics of the meat, except the fatty acid profile. The meat from animals...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Publication date: Available online 20 February 2020Source: Veterinary ParasitologyAuthor(s): Marei B. Haehling, Giovanna G. Cruvinel, João H.B. Toscano, Luciana A. Giraldelo, Isabella B. Santos, Sergio N. Esteves, Magda V. Benavides, Waldomiro Barioni Júnior, Simone C.M. Niciura, Ana Carolina. S. ChagasAbstractGastrointestinal nematodes are a major constraint in sheep production. Breeding for resistance has proven to be an effective and feasible approach to address this problem. The use and investigation of genetic markers for resistance traits could accelerate genetic progress and lead to a better understand...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
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