Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer

Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in type-2 diabetes (Rui et al., 2002). However, such challenges can be met by using SOCS1 mimetic peptide lacking the SOCS Box domain. As of now, SOCS1 gene therapy and mimetic-peptide biologics are active areas of research around the globe. Jakinibs have gained a great deal of attention in the last two decades for their efficacy in cancer and autoimmune diseases and we believe SOCS1 mimetics would be a great addition to the arsenal of jakinibs. Nonetheless, detailed safety and efficacy studies need to be carried before directly comparing SOCS1 mimetics to other jakinibs. Author Contributions JS and JL wrote the manuscript. JS designed the figures. JL reviewed the figures. Funding Research in JL lab was supported by the Lupus Research Institute, National Psoriasis Foundation Awards to the University of Florida. Conflict of Interest Statement The authors d...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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