Identification of genetic alterations in extramammary Paget disease using whole exome analysis

Extramammary Paget disease (EMPD) is a rare cutaneous adenocarcinoma that most commonly affects the genital and the perianal area of elderly patients [1]. Cancerous cells are thought to originate from apocrine glands in the epidermis and subsequently invade the dermis. Metastatic EMPD is difficult to control using cytotoxic agents and radiation therapy, and the development of novel systemic therapies would be very beneficial.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research