Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review

The pathogenesis of psoriasis may involve a breakdown of immune tolerance to cutaneous microorganisms. Psoriasis is associated with a higher incidence of Crohn disease and periodontitis, two diseases involving impaired tolerance and abnormal immune activation in response to intestinal and oral microbiota, respectively. In addition, guttate and chronic plaque psoriasis are associated with Streptococcus pyogenes colonization. The aim of this review is to characterize the microorganisms implicated in psoriasis by examining results of major association studies and possible mechanisms of pathogenesis.

Source: Clinics in Dermatology - February 28, 2019 Category: Dermatology Authors: Daniel J. Lewis, Warren H. Chan, Tiffany Hinojosa, Sylvia Hsu, Steven R. Feldman Tags: Investigative Rounds Source Type: research