Skin Directed Therapy in Cutaneous T-Cell Lymphoma

Skin Directed Therapy in Cutaneous T-Cell Lymphoma Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as well as some newer/targeted methodologies. Radiation therapy, including localized radiation and total skin electron beam therapy, continues to be a cornerstone of therapy for all stages of MF. Introduction Skin directed therapies (SDTs) in cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF) serve important roles in treating disease, but also in treating symptoms. Although SDTs can be used to cure CTCL in some patients with limited or early stage MF (stage 1A, 1B), they are most often used with palliative intent at all stages (1), with adjunct roles for both treatment and symptom management in more advanced MF, particularly managing pruritus and maintaining the skin barrier. The current National Comprehensive Cancer Network (NCCN) guidelines (1) recommend a general list of SDTs, but do not dictate ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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