Association of Leptin Gene DNA Methylation With Diagnosis and Treatment Outcome of Anorexia Nervosa

Association of Leptin Gene DNA Methylation With Diagnosis and Treatment Outcome of Anorexia Nervosa Alexandra Neyazi1†, Vanessa Buchholz1†, Alexandra Burkert1, Thomas Hillemacher1,2, Martina de Zwaan3, Wolfgang Herzog4, Kirsten Jahn1, Katrin Giel5, Stephan Herpertz6, Christian A. Buchholz1, Andreas Dinkel7, Markus Burgmer8, Almut Zeeck9, Stefan Bleich1, Stephan Zipfel5† and Helge Frieling1*† 1Molecular Neuroscience Laboratory, Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School (MHH), Hannover, Germany 2Department of Psychiatry and Psychotherapy, Paracelsus Medizinische Privatuniversität Nürnberg, Nuremberg, Germany 3Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School (MHH), Hannover, Germany 4Department of Psychosomatic Medicine and Psychotherapy, University of Heidelberg, Heidelberg, Germany 5Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, Tübingen, Germany 6Department of Psychosomatic Medicine and Psychotherapy, LWL University Clinic Bochum, Bochum, Germany 7Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany 8Department of Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany 9Department of Psychosomatic Medicine and Psychotherapy, Center of Mental Disorders, University Medical Center Freib...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Publication date: Available online 19 June 2019Source: Journal of Molecular LiquidsAuthor(s): Takahiro To, Hiroaki Mizusaki, Asami Murai, Masaru Matsugami, Toshiyuki TakamukuAbstractTo clarify the unique solvation properties of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) on a biomolecule of L-phenylalanine (Phe), the solvation structure of Phe in HFIP-water mixed solvents at 70 mmol dm−3 has been observed over the entire range of HFIP mole fraction xHFIP using infrared (IR), 1H and 13C NMR techniques with a help of molecular dynamics (MD) simulation. The solvation structure of Phe in the HFIP solvents has been compa...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Authors: Jenabi E, Bashirian S, Khazaei S, Basiri Z Abstract This meta-analysis evaluated the association between maternal pre-pregnancy body mass index (BMI) and the risk of attention deficit hyperactivity disorder (ADHD) among children and adolescents. The search strategy was conducted until December 2018 in databases of PubMed, Web of Science and Scopus. The ORs or HRs with 95% confidence intervals (CI) extracted from eligible studies used as the common measure of association among studies. A significant association was found between overweight women and risk of ADHD among children with the pooled estimates of H...
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research
In this study, we found that miR-122 expression was increased in the aortic ECs of ApoE−/− mice fed with a high-fat diet (HFD), as compared to normal-diet (ND), implying a potential association between miR-122 elevation and atherogenesis. In addition, in vitro, miR-122 expression was also induced in human aortic ECs (HAECs) by the treatment of oxidized low-density lipoprotein (ox-LDL), a common atherogenic factor. Functionally, miR-122 knockdown suppressed ox-LDL-induced apoptosis of HAECs, suggesting a pro-apoptotic role of miR-122 in HAECs under this pro-atherogenic condition. Further evidence revealed that t...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 June 2019Source: Carbohydrate PolymersAuthor(s): P. Pramod Kumar, Harish Prashanth K.V.ABSTRACTAcrylamide (AA) presence and formation are predominant in fried, baked and heat-processed foods. Using Drosophila model, we have investigated the dietary AA-arbitrate oxidative stress induced neurotoxicity and the effect of soluble Low Molecular Weight Chitosan (LMWC) supplementation. We assessed the neurodegenerative and behavioural effect of AA (0-10 mM) exposure in Drosophila (adult males). As a result, the exposed flies showed distinctive locomotor impairments and incident of morta...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 June 2019Source: Chemico-Biological InteractionsAuthor(s): Nellore Bhanu Chandar, Irena Efremenko, Israel Silman, Jan M.L. Martin, Joel L. SussmanAbstractAlthough the three-dimensional structures of mouse and Torpedo californica acetylcholinesterase are very similar, their responses to the covalent sulfonylating agents benzenesulfonyl fluoride and phenylmethylsulfonyl fluoride are qualitatively different. Both agents inhibit the mouse enzyme effectively by covalent modification of its active-site serine. In contrast, whereas the Torpedo enzyme is effectively inhibited by benzenesulfony...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
This study demonstrates the mechanism of action of the natural compound hassallidin, and gives further insight into how bioactive lipopeptide metabolites selectively target eukaryotic cell membranes.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: October 2019Source: The Journal of Supercritical Fluids, Volume 152Author(s): L. Teeter, R. Repukaiti, N. Huerta, R.P. Oleksak, R.B. Thomas, Ö.N. Doğan, M. Ziomek-Moroz, J.D. TuckerAbstractThe corrosion resistance of high-strength low-alloy carbon steel was investigated in simulated conditions that exist in direct supercritical CO2 power cycle heat exchangers. The experiments were performed at 80 bar for 500 h at either 50 °C with samples exposed to H2O-saturated CO2 and CO2-saturated H2O or 250 °C undersaturated CO2. Exposures were conducted with and without O2.Corrosion rates were determin...
Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
Publication date: Available online 19 June 2019Source: Polymer TestingAuthor(s): Mahdi Ashrafi, Ahmad Reza Ghasemi, Masood HamadanianAbstractThis work aimed to develop mechanical/thermal properties of polymer-based nanocomposite in aerospace applications. Hence, herein nanocomposites were prepared through the direct blending of epoxy (EP) with Polyethylene glycol (PEG) and multiwalled carbon nanotubes (MWCNTs) as filler. Weight fraction of fillers was optimized by central composite design (CCD) to get maximum tensile strength and elongation. Interestingly, cross-section scanning electron microscopy (cross-section SEM) and ...
Source: Polymer Testing - Category: Chemistry Source Type: research
Publication date: Available online 18 June 2019Source: Polymer TestingAuthor(s): Xingguo Wang, Jun Sun, Xiaodong Liu, Shengling Jiang, Julin Wang, Hongfei Li, Serge Bourbigot, Xiaoyu Gu, Sheng ZhangAbstractAn effective flame retardant N, N′-bis [salicylidene hypophosphorous acid]-1, 2-ethylenediamine (SHPE) was synthesized by a Kabachnik-Fields reaction between hypophosphorous acid and a Schiff base compound. The chemical structure was confirmed by FTIR, 1HNMR and organic element analysis. SHPE was melt blended with poly (lactic acid) (PLA) matrix to enhance the flame retardancy. Fire behavior evaluation of PLA compo...
Source: Polymer Testing - Category: Chemistry Source Type: research
Publication date: Available online 18 June 2019Source: Polymer Degradation and StabilityAuthor(s): Miroslav Šlouf, Danuše Michálková, Veronika Gajdošová, Jiří Dybal, Jan PilařAbstractPolymer plaques made of high density polyethylene (HDPE) and of two types of cycloolefin copolymer (COC) differing in glass transition temperature, were stabilized with 0.2 or 1.0 wt % of natural (α-tocopherol) or synthetic (Irganox®1010) phenolic stabilizer or hindered amine stabilizer (Tinuvin®770) and aged using accelerated weathering technique (WOM). The efficiency of the p...
Source: Polymer Degradation and Stability - Category: Chemistry Source Type: research
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