Dartmouth Researchers Offer New Insights into How Maternal Immunity Impacts Neonatal HSV

Findings from a Dartmouth-led study published in the journal Science Translational Medicine, are offering new insights into neonatal herpes, its impact on developing nervous systems, and how newborns can be protected from the disease. In this innovative study, investigators were able to measure not only mortality but also neurological consequences of infection in mice who acquired the virus.
Source: News at Dartmouth Medical School - Category: Hospital Management Authors: Tags: News Press Release Research David Leib herpes HSV immunology neonatal HSV Source Type: news

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Abstract This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. PMID: 31005137 [PubMed - in process]
Source: Herpes - Category: Infectious Diseases Authors: Tags: Infect Dis Clin North Am Source Type: research
Authors: Yamaoka K Abstract INTRODUCTION: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Expert commentary: The efficacy of tofacitinib monotherapy has garnered much attention and has been initiated in a fairly larg...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Herpes zoster is viewed as indicator of immunosuppression. Sometimes is also a maker for HIV, malignancy. Young adult suffered from herpes zoster is less common than old patient. There are some studies found that ocular involvement in young adult may suspect HIV infection. However, there are no answers whether early onset herpes zoster (20-49 year old) association malignancy or not. The study used non-sample claims data of the National Health Insurance of Taiwan in 2000-2010. 121104 patients newly diagnosed early onset HZ is included and randomly selected non-HZO cohort (N=484416) frequency matched by sex, age and diagnosi...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
The IL-36 cytokines are associated with inflammation in psoriasis and bacterial infections. Recent work has suggested that the IL-36 cytokines also protect against viral infections; however, the mechanism of action has remained unknown. We here report a novel pathway whereby IL-36 promotes innate antiviral immunity in both mouse and human models of herpes simplex virus-1 (HSV-1) infections. Specifically, we find that IL-36 β deficient mice poorly restrict viral replication in skin keratinocytes and have diminished expression of the antiviral protein Mx1.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
When we are born, our blood contains antibodies that we have inherited from our mothers. They are transferred across the placenta and provide protection from infection until IgG production begins around 15 weeks after birth. Can we exploit such antibody transfer by vaccinating pregnant mothers to protect newborns against infectious diseases that occur early after […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information antibody cord blood herpes simplex virus herpes vaccine IgG neonatal herpes passive immunization transplacental passage viral viruses Source Type: blogs
In this study, we compared these variables in extraorbital lacrimal gland (EoLG) after corneal HSV-1 infection in the C57BL/6J mouse model. Our results showed a significant reduction in the volume of tears in infected eyes during the development of HSK. Extensive architectural damage to EoLG, presumably caused by a massive influx of interferon-gamma secreting T cells, was observed during clinical disease period of HSK. A positive correlation between the decrease in tear volume, severity of HSK and the damage to EoLG were evident in infected mice. The presence of infectious virus measured in EoLG during pre-clinical, but no...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
Conclusions: Studies on the predictors of severity in drug reaction with eosinophilia and systemic symptoms in different population groups may enable us to identify the warning signs and help to formulate the standard therapeutic guidelines.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
Publication date: June 2019Source: Infectious Disease Clinics of North America, Volume 33, Issue 2Author(s): Sanjeet Singh Dadwal
Source: Infectious Disease Clinics of North America - Category: Infectious Diseases Source Type: research
(Harvard Medical School) Now research conducted in mice offers new hope that neonatal herpes infections might eventually be avoidable by stimulating an immune response in mothers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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