Stem Cell Treatment Cures Very Early Onset Irritable Bowel Syndrome
Baby Zhao was diagnosed with Very Early Onset Irritable Bowel Syndrome, VEO-IBS, just a few days after she was born. This worried Zhao’s parents because they lost their previous daughter to the same disease when she was just a few months old. VEO-IBS is caused by an inherited genetic mutation and is not easily or successfully treated with medications. While some medications may help with mild relief for symptoms, patients are usually severely malnourished and experience pain and discomfort due to intestinal abscesses and fistulas. Dr. Huang Ying, MD PhD, the director of the Digestive Disease Department at Children’s Hospital of Fudan University in China where Zhao was being seen, believed in only one solution: a stem cell transplant. Zhao had a stem cell transplant at the Children’s Hospital of Fudan University in 2015. Because Zhao’s treatment was successful, doctors decided to treat eight other children with her same condition. The transplants were performed with reduced chemotherapy condition to lessen the toxicity of the procedure for the patients. A few months following her stem cell transplant, Zhao has experienced normal intestinal function and, according to her parents, was finally able to put on some healthy baby weight! As a parent, the health and well-being of your newborn baby becomes top priority. Motherly (and fatherly) instincts kick in so you can provide your baby with everything they may possibly need. Seeing your baby suffer in pain b...
Conclusions: ELS-induced visceral pain and visceral hypersensitivity are associated with the underfunction of SK2 channels in the spinal DH. PMID: 33029124 [PubMed - in process]
Conclusion: EA can regulate the P2X3 receptor protein and mRNA expression levels in the colon and related DRG of IBS rats with visceral pain and then regulate the excitatory properties of DRG neurons. PMID: 33014041 [PubMed]
Conclusion: In a c ohort of Greek FD patients, SIBO prevalence was similar to that of IBS subjects and higher compared to that of controls.
We describe how to take a detailed history, perform meticulous digital rectal examination, and use validated tools to supplement clinical evaluation, including assessments of quality of life and scoring systems for disease severity and digital Apps. These tools could facilitate a comprehensive plan for clinical management including diagnostic tests, and translate the patients' complaints into definable, diagnostic categories. PMID: 32989182 [PubMed]
CONCLUSION: These findings highlight the importance of psychologic functioning in the assessment and management of these overlapping pain conditions. PMID: 32975543 [PubMed - as supplied by publisher]
CONCLUSION: Atopic disorders, previously recognized as predictors of poor sleep, are associated with COPCs after accounting for sleep problems. PMID: 32975542 [PubMed - as supplied by publisher]
Authors: Sharma S, Slade GD, Fillingim RB, Greenspan JD, Rathnayaka N, Ohrbach R Abstract AIMS: To investigate whether TMD-related characteristics are indeed specific to TMD or whether they are also associated with other chronic overlapping pain conditions (COPCs). METHODS: In this cross-sectional study, 22 characteristics related broadly to TMD (eg, jaw kinesiophobia, overuse behaviors, and functional limitation) were measured in 178 painful TMD cases who were also classified according to four COPCs: headache, low back pain, irritable bowel syndrome, and fibromyalgia. Differences in mean subscale scores were c...
CONCLUSION: When evaluating nociceptive sensitivity in a chronic pain patient, comorbid pain conditions should be considered, as the more salient feature underlying sensitivity is likely the number rather than the type(s) of pain conditions. PMID: 32975540 [PubMed - as supplied by publisher]
CONCLUSION: Heat maps from a pain body manikin illustrated that very little of the body was pain free within these COPCs. All pain attributes were the most severe for fibromyalgia and the least severe for irritable bowel syndrome. Within each index COPC, pain intensity, pain interference, and the proportion of participants with high-impact pain increased with each additional comorbid COPC up to four or more COPCs (including the index COPC) (P
CONCLUSION: There was greater overlap between fibromyalgia and either temporomandibular disorders or low back pain than between other pairs of COPCs. While musculoskeletal conditions exhibited some features that could be explained by a single functional syndrome, headache and irritable bowel syndrome did not. PMID: 32975538 [PubMed - as supplied by publisher]