The Role of Exosome in Autoimmune Connective Tissue Disease.

The Role of Exosome in Autoimmune Connective Tissue Disease. Ann Med. 2019 Apr 09;:1-15 Authors: Zhu T, Wang Y, Jin H, Li L Abstract Exosomes have generated significant interest in the last few decades owing to their important roles in a diverse range of biological pathways. They are nano-sized lipid bilayer membrane vesicles of endosomal origin, and are produced by a vast number of cell types. They are released into the extracellular environment and are found in most biological fluids. Exosomes can contain proteins, lipids, and nucleic acids. The cargo of exosomes allows them to play roles in cell communication, antigen presentation, as biomarkers, and in immune regulation. Substantial efforts have been made to understand their biology and potential clinical use in various diseases, including autoimmune connective tissue diseases (ACTD). In this review, we highlight the known functions of exosomes and detail recent advances made in the elucidation of the roles of exosomes in ACTDs with an emphasis on their potential use as a biomarker for disease diagnosis and as a therapeutic target. PMID: 30961395 [PubMed - as supplied by publisher]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research