Dartmouth researchers offer new insights into how maternal immunity impacts neonatal HSV

(The Geisel School of Medicine at Dartmouth) Findings from a Dartmouth-led study published in the journal Science Translational Medicine, are offering new insights into neonatal herpes, its impact on developing nervous systems, and how newborns can be protected from the disease. In this innovative study, investigators were able to measure not only mortality but also neurological consequences of infection in mice who acquired the virus.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they are important therapeutic targets. We established PCSC-enriched spheres by culturing human (DU145) and murine (TRAMP-C2) PCa cells in growth factor-defined serum-free medium, and we characterized stem-like properties of clonogenicity and tumorigenicity. The efficacy of two different oncolytic herpes simplex viruses (oHSVs) (G47Δ and MG18L) in PCSCs was tes...
Source: Herpes - Category: Infectious Diseases Authors: Tags: Mol Ther Oncolytics Source Type: research
Abstract Chimeric antigen receptor (CAR) is a hybrid molecule consisting of an antigen-binding domain and a signal transduction domain. The artificial T cells expressing CAR (CAR-T cells) are expected to be a useful tool for treatment of various diseases, such as cancer. The addition of a co-stimulatory signal domain (CSSD) to CAR is shown to be critical for modulating CAR-T cell activities. However, the interplay among types of CSSDs, effector functions, and characteristics of CAR-T cells is largely unknown. To elucidate the interplay, we analyzed effector functions, differentiation to memory T cell sub...
Source: Herpes - Category: Infectious Diseases Authors: Tags: Mol Ther Oncolytics Source Type: research
This article reviews the treatment of herpes simplex virus, cytomegalovirus, hepatitis B and C viruses, and human immunodeficiency virus during pregnancy. PMID: 31010558 [PubMed - in process]
Source: Herpes - Category: Infectious Diseases Authors: Tags: Clin Perinatol Source Type: research
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, our results showed that CMV infection may play a role in the initiation or amplification of inflammatory responses in AOSD. Introduction Adult-onset Still's disease (AOSD) is a rare but clinically well-known systemic inflammatory disease. It is typically characterized by a high spiking fever, evanescent skin rash, arthralgia, sore throat and neutrophilia (1–3). Even though the etiology of AOSD remains unknown, there is evidence that it's triggered by environmental factors with genetic predisposition (4). It has long been suspected that viral infections might contribute to the on...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we showed that KSHV-infected cells induce interferon-stimulated genes (ISGs) response but not type I interferon in uninfected bystander cells using EVs. mRNA microarray analysis showed that ISGs and IRF-activating genes were prominently activated in EVs from KSHV-infected cells (KSHV EVs)-treated human endothelial cells, which were validated by RT-qPCR and western blot analysis. We also found that this response was not associated with cell death or apoptosis by virus infection. Mechanistically, the cGAS-STING pathway was linked with these KSHV EVs-mediated ISGs expressions, and mitochondrial DNA on the surfa...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31017658 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Abstract This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. PMID: 31005137 [PubMed - in process]
Source: Herpes - Category: Infectious Diseases Authors: Tags: Infect Dis Clin North Am Source Type: research
Authors: Yamaoka K Abstract INTRODUCTION: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Expert commentary: The efficacy of tofacitinib monotherapy has garnered much attention and has been initiated in a fairly larg...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Herpes zoster is viewed as indicator of immunosuppression. Sometimes is also a maker for HIV, malignancy. Young adult suffered from herpes zoster is less common than old patient. There are some studies found that ocular involvement in young adult may suspect HIV infection. However, there are no answers whether early onset herpes zoster (20-49 year old) association malignancy or not. The study used non-sample claims data of the National Health Insurance of Taiwan in 2000-2010. 121104 patients newly diagnosed early onset HZ is included and randomly selected non-HZO cohort (N=484416) frequency matched by sex, age and diagnosi...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
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