Organ transplant: finding more ways to save lives

By using organs once thought to be unsuitable, tapping the liver ’s power to regenerate, and more, Yale Medicine experts are making the most of organ donations.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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Authors: Shimata K, Irie T, Kadohisa M, Kawabata S, Ibuki S, Narita Y, Yamamoto H, Sugawara Y, Hibi T Abstract Adhesions due to previous upper abdominal surgery may complicate later liver transplantation. Here we report successful living donor liver transplantation (LDLT) in a patient with a history of total gastrectomy. A 32-year-old Japanese woman developed end-stage liver failure due to alcoholic cirrhosis. She had undergone total gastrectomy, pancreato-splenectomy, and partial colectomy due to rupture of a pancreatic cyst. LDLT was performed using a right lobe graft from her sister. To minimize blood loss and i...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
Researchers from Israel have created a 3D-printed model that captures the immunological,...Read more on AuntMinnie.comRelated Reading: 3D printing reduces liver transplant costs, surgery time 3D printing helps separate rare case of conjoined twins 3D printing technique improves heart valve sizing 3D-printed aortas could work well for TAVR Flexible 3D-printed heart replicates size, texture
Source: Headlines - Category: Radiology Source Type: news
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co-inhibitor...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: We have shown that severity of MWS symptoms gradually increased with age toward distinct generation-specific phenotypes. A uniform trajectory of disease evolution has encouraged us to postpone institution of IL-1 blockade in affected oligosymptomatic children. This report illustrates importance of close interdisciplinary collaboration. Introduction Cryopyrinopathies (Cryopyrin Associated Periodic Syndromes, CAPS) belong to autoinflammatory disorders with autosomal dominant inheritance caused by the gain-of-function point mutation of NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) gene which en...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion In this section, we discuss the mechanisms responsible for lymphomagenesis in the various inborn errors of immunity and provide an overview of the treatment. Defects in Immune Responses That Predispose to Lymphomagenesis in PIDDs The complex immune mechanisms and their interplay that predisposes to neoplastic transformation of B or T cells and development of lymphomas in PIDD patients has not been fully elucidated. However, it is expected that the etiology in most cases is multifactorial and related to a dynamic regulation of immune response and environmental triggers (Figure 3). An underlying intrinsic susce...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: The link between novel fusion transcript VTI1A-CFAP46 and autophagy as a potential therapeutic target in HCC patients deserves further investigation. Moreover, this study shows that fusion transcripts are worthy of additional exploration in HCC.Gastrointest Tumors
Source: Gastrointestinal Tumors - Category: Gastroenterology Source Type: research
Does coffee consumption reduce the risk of hepatocellular carcinoma recurrence after liver transplantation?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Early liver transplantation (without requiring a minimum period of sobriety) for severe alcohol-associated hepatitis (AH) is controversial —many centers delay eligibility until a specific period of sobriety (such as 6 months) has been achieved. To inform ongoing debate and policy, we modeled long-term outcomes of early vs delayed liver transplantation for patients with AH.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of deranged liver blood tests (LFTs) in primary care in Europe and North America [1], and has an estimated prevalence of 25-30% in the adult population[2]. Only a minority of people with NAFLD (5%) develop clinically significant liver disease [2], but the burden is such that NAFLD is predicted to be the leading indication for liver transplantation within a decade[3].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Publication date: Available online 12 April 2019Source: Molecular Genetics and MetabolismAuthor(s): Carlos R. Ferreira, David Cassiman, Nenad BlauAbstractInherited metabolic diseases account for about one third of pediatric patients with hepatomegaly, acute liver failure, cirrhosis or cholestasis. Specifically for pediatric acute liver failure, they account for 10–15% of cases, with a mortality of 22–65%. The percentage of acute liver failure caused by an inherited metabolic disease in children
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
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