Rheumatoid arthritis warning - do your hands feel like this? Hidden tingling symptoms

RHEUMATOID arthritis symptoms include joint pain, inflammation and restricted movement. But the condition, which affects around 400,000 people in the UK, could also cause a hidden tingling symptom. Are your hands affected by this sign?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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In this study, we evaluated the effect of auranofin on the radiosensitivity of intestinal epithelial cells. The treatment with a combination of 1 μM auranofin and 5 Gy ionizing radiation showed clear additive effects on caspase 3 cleavage and apoptotic DNA fragmentation in IEC-6 cells, and auranofin administration significantly aggravated the radiation-induced intestinal injury in mice. Auranofin treatment also resulted in the activation of the unfolded protein response and in the inhibition of thioredoxin reductase, which is a key component of the cellular antioxidant system. Pre-treatment with N-acetyl cysteine, a wel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: The present study suggests that the extract of LMZ attenuates CFA-induced inflammatory pain by suppressing the ERK1/2 and NF-κB signaling pathway at both peripheral and central level. Introduction Pain is one of the most common symptoms in clinical practice, and inflammatory pain is the most important type of pain (Patapoutian et al., 2009). Inflammatory pain is a growing global health problem. In generally, there is a common course of progression in inflammation and pain share. When patients experience inflammation, they may develop hyperalgesia or allodynia to various mechanical, thermal, or che...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study was supported by the Swiss National Science Foundation No. 31-124861 to GS. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2019.00414/full#supplementary-material References Chava, K. R., Tauseef, M., Sharma, T., and Mehta, D. (2012). Cyclic AMP response element-binding protein prevents endothelial permeability...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The Monarch external Trigeminal Nerve Stimulation (eTNS) System made history last week after it became the first device to win a nod from FDA to treat attention deficit hyperactivity disorder (ADHD). It should be noted the technology has had CE mark since 2015. Monarch was developed by NeuroSigma and is indicated to help treat 7 to 12-year-olds suffering from ADHD. What makes this de novo clearance from FDA so significant is that typically pharmaceutical solutions are used to treat patients suffering from the neurological disorder. Monarch is about the size of a cellphone. The device generates a low-level electrical pulse ...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
ConclusionIn this study, patients with early rheumatoid arthritis had a high ‐frequency unacceptable pain and wide spread pain, irrespective of smoking status. However, we cannot exclude that the inflammatory‐associated pain overshadowed a possible negative effect of smoking.
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 17 April 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): George S. Metsios, George D. KitasAbstractRheumatoid arthritis (RA) is characterised by functional disability, pain, fatigue and body composition alterations that can further impact on the physical dysfunction seen in RA. RA is also associated with systemic manifestations, most notably an increased risk for cardiovascular disease. There is strong evidence to suggest that increasing physical activity and/or exercise can simultaneously improve symptoms and reduce the impact of systemic manifestations in RA. How...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionRA individuals had a more negative perception of their OHRQoL compared with individuals with no RA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Decision Resources Group (DRG) released a new report today, "4 Crazy Medtech Innovations" that identifies four areas of medtech innovation that are forecasted to shake up the treatment landscape within the next five years. "The reason we decided to look at crazy innovation in medtech was that a few people on our consulting team were doing that and to help them out we decided to do a scan talking to our different data experts, therapy experts, [to learn] what have people seen that's actually crazy innovation," Lexie Code, director of medtech learning at DRG, told MD+DI. After gathering intel from each of...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
ConclusionsThe leaves and stems, just as the roots, have antiarthritic and analgesic effects and can be used as more sustainable alternatives to the roots. This will support the continuous growth of the industry that has developed around C. erythrocarpos.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Siriluck Ponsuksili1, Nares Trakooljul1, Frieder Hadlich1, Karen Methling2, Michael Lalk2, Eduard Murani1 and Klaus Wimmers1,3* 1Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Functional Genome Analysis Research Unit, Dummerstorf, Germany 2Institute for Biochemistry – Metabolomics, University of Greifswald, Greifswald, Germany 3Faculty of Agricultural and Environmental Sciences, University of Rostock, Rostock, Germany Given the central metabolic role of the liver, hepatic metabolites and transcripts reflect the organismal physiological state. Biochemical-clinical plasma bio...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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