Clinical implications of discrepant results between genotypic MTBDRplus and phenotypic L öwenstein-Jensen method for isoniazid or rifampicin drug susceptibility tests in tuberculosis patients.

Conclusions: Despite the low frequency, discordant results were obtained between the genotypic and phenotypic DSTs for INH or RIF, especially for patients with MDR TB or INH resistance. Furthermore, it seemed that RIF discrepancy with a genotypic mutation might have a greater impact on the clinical outcome than INH discrepancy. PMID: 30962983 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research