Connecting Mind, Brain, and Seizures by Default Mode.

Connecting Mind, Brain, and Seizures by Default Mode. Epilepsy Curr. 2019 Mar-Apr;19(2):103-104 Authors: Salpekar J Abstract Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings From the Epilepsy Connectome Project Cook CJ, Hwang G, Mathis J, et al. Brain Connect. 2018. doi:10.1089/brain.2018.0600. [Epub ahead of print]; PMID: 30398367 The Epilepsy Connectome Project examines the differences in connectomes between patients with temporal lobe epilepsy (TLE) and healthy controls. Using these data, the effective connectivity of the default mode network (DMN) in patients with left TLE compared to healthy controls was investigated using spectral dynamic causal modeling of resting state functional magnetic resonance imaging data. Group comparisons were made using 2 parametric empirical Bayes (PEB) models. The first level of each PEB model consisted of each participant's spectral dynamic causal modeling. Two different second-level models were constructed: the first comparing effective connectivity of the groups directly and the second using the Rey Auditory Verbal Learning Test (RAVLT) delayed free recall index as a covariate at the second level in order to assess effective connectivity controlling for the poor memory performance of patients with left TLE. After an automated search over the nested parameter space and thresholding parameters at 95% posterior probability, both models revealed numerou...
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research