Aortic Wall Elastic Properties in Case of Bicuspid Aortic Valve

Aortic Wall Elastic Properties in Case of Bicuspid Aortic Valve Guillaume Goudot1, Tristan Mirault2,3, Patrick Bruneval2,4, Gilles Soulat5, Mathieu Pernot1 and Emmanuel Messas2,3* 1INSERM U1273, ESPCI Paris, CNRS FRE 2031, Physics for Medicine Paris, PSL Research University, Paris, France 2Centre de Référence des Maladies Vasculaires Rares, Hôpital Européen Georges-Pompidou, Assistance Publique – Hôpitaux de Paris (APHP), Paris, France 3INSERM U970 PARCC, Paris Descartes University – Sorbonne Paris Cité University, Paris, France 4Service d’Anatomie Pathologique, Hôpital Européen Georges-Pompidou, Assistance Publique – Hôpitaux de Paris (APHP), Paris, France 5Service de Radiologie Cardiovasculaire, Hôpital Européen Georges-Pompidou, Assistance Publique – Hôpitaux de Paris (APHP), Paris, France Purpose of the Review: Bicuspid aortic valve (BAV) is associated with a significant risk of development of aneurysm and dissection of the ascending thoracic aorta. Development of what is called BAV associated aortopathy is particularly heterogeneous with an uncertain prognosis and with no prognostic biomarkers except for the aortic diameter. This situation leads to an important variability of the therapeutic strategy of this aortopathy. By reviewing the literature on aortic stiffness in the case of BAV, we aimed at evaluating its potential prognostic role in the develo...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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ConclusionThis review shows that CAM may be useful for ALS treatment, but more evidence regarding the efficacy and molecular mechanisms is required to establish CAM as a good therapy for the treatment of ALS patients.
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research
ConclusionResearch-related curricular interventions in the Chinese medicine field should directly address model validity, as it is of significant interest to a majority of students.
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research
Publication date: Available online 19 October 2019Source: Canadian Journal of CardiologyAuthor(s): Patrick Meagher, Mohamed Adam, Kim Connelly
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
In this study, seven solutions, i.e., GPS-only (G), GLONASS-only (R), BDS-only (C), GPS+BDS (GC), GPS+ GLONASS (GR), GLONASS+BDS (RC), GPS+GLONASS+BDS (GRC), are used to test the regional ionosphere modeling over the experimental area. Moreover, the performances of them using single-frequency precise point positioning (SF-PPP) method are presented. The experimental results indicate that BDS has the same ionospheric monitoring capability as GPS and GLONASS. Meanwhile, multi-GNSS observations can significantly improve the accuracy of the regional ionospheric models compared with that of GPS-only or GLONASS-only or BDS-only, ...
Source: Advances in Space Research - Category: Science Source Type: research
Publication date: Available online 18 October 2019Source: Stem Cell ResearchAuthor(s): Jingyun Guan, Xiaolin Liu, Haiyan Zhang, Yuqiang Lv, Xiaojing Wang, Xiaomeng Yang, Yanyan Ma, Qiji Liu, Yi Liu, Wenjie SunAbstractCUL4B gene mutation can cause intelligence deficiency 15, a syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, speech delay and impairment, tremor and gait ataxia. Here, we generated iPSCs from a Chinese patient with c.1007_1011del (p.(Ile336fs)) in CUL4B gene by reprogramming peripheral blood mononuclear cells wit...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 18 October 2019Source: Materials Science and Engineering: AAuthor(s): Xuan Zhao, Shiyun Dong, Shixing Yan, Xiaoting Liu, YuXin Liu, Dan Xia, Yaohui Lv, Peng He, Binshi Xu, Hongsheng HanAbstract24CrNiMo alloy steel is a low-alloy high strength steel and was used to fabricate engine components and brake discs. In the current study, Direct Laser Deposition (DLD) was used to additively manufacture 24CrNiMo alloy steel samples with high strength and ductility. The microstructural evolution, texture and mechanical properties of deposited samples can be affected by changing inter-layer time inte...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Conclusion: Our study is designed to highlight how fibrofatty changes are minimal using CMRI in the pediatric population and how this can be a valuable tool to provide an additional method of diagnosis. PMID: 31625461 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Authors: Ogasawara N, Saitoh S, Denpou H, Kinowaki K, Akuta N, Suzuki F, Hashimoto M, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Kobayashi M, Suzuki Y, Arase Y, Ikeda K, Fujii T, Kumada H Abstract We herein report a 48-year-old healthy woman who visited our hospital to investigate a 25-mm space-occupying lesion in the liver. The tumor was irregularly shaped and exhibited heterogeneous enhancement on dynamic computed tomography (CT). Whole-body positron emission tomography-CT showed an abnormal fluorodeoxyglucose uptake in the liver tumor, with a maximum standardized uptake value of 12.82. During the ensuing three ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
In this study, we investigated a Chinese medicine (CM) formulation named NeuroDefend (ND), for reducing amyloid β (Aβ) and tau pathology in transgenic AD mice models. Regular oral administration of ND improved cognitive function and memory in 3XTg-AD and 5XFAD mice. In addition, ND reduced beta-amyloid precursor protein (APP), APP C-terminal fragments (CTF-β/α), Aβ and 4G8 positive Aβ burden in 3XTg-AD and 5XFAD mice. Furthermore, ND efficiently reduced the levels of insoluble phospho-tau protein aggregates and AT8 positive phospho tau neuron load in 3XTg-AD mice. Hence, ND could be a promisi...
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research
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