Aortic Wall Elastic Properties in Case of Bicuspid Aortic Valve
Conclusion
Regardless of age, presence of valvular dysfunction, sporadic, genetic or syndromic forms of BAV patients, early and segmental changes in the aortic wall result in an excess of wall stiffness as compared to patients with a normal TAV. These results are consistent with the histological aspect of BAV associated aortopathy with marked lesions of elastin fibers destruction and mucoid material replacement. Aortic stiffness markers require a better reliability and long-term evaluation to conclude on their useful prognostic roles. Standardization of stiffness parameters, coupling to flow data, and perhaps evaluation of aortic stiffening could allow clinical parameters to be developed in the near future for prognostic purposes on the risk of dilatation and possibly acute aortic event.
Author Contributions
GG and TM wrote the manuscript. PB proofread the histology part of the manuscript. GS proofread the part of the manuscript concerning the evaluation of the aorta by magnetic resonance imaging. MP proofread the part of the manuscript concerning the biomechanical properties of the aorta as well as the ultrasound evaluation. EM performed the final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy and integrity of any part of the work are appropriately investigated and resolved.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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