Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

Conclusion: Mitofusin 2 promotes Parkin translocation and phosphorylation, leading to mitophagy to clear damaged mitochondria. However, the beneficial effects of MFN2 were reversed by autophagy inhibitors. Additionally, MFN2 participates in mitochondrial fusion to maintain mitochondrial quality. Thus, MFN2 participated in mitophagy and mitochondrial fusion against Ang II-induced cardiomyocyte injury. Introduction Ventricular remodeling is the core foundation for the development of heart failure (Hill and Olson, 2008). Pathological remodeling is typically due to a number of causes that result in increased pressure or volume, causing pressure or volume overload in the heart (Burchfield et al., 2013). This pathological process may include ventricular hypertrophy, ventricular dilation, cardiomegaly, and other changes. Ultimately, ventricular remodeling results in heart failure. Neurohumoral stimulation and mechanical stress are the major triggers of ventricular remodeling. Ang II can activate a number of signaling pathways to induce cardiac inflammation, hypertrophy, and fibrosis, thus leading to ventricular remodeling (Mehta and Griendling, 2007; Trachtenberg and Hare, 2017). Additionally, ventricular remodeling involves mitochondrial metabolism, oxidative stress, and autophagy (Maillet et al., 2013; van Berlo et al., 2013; Zhou et al., 2013; Lyon et al., 2015). In recent years, insufficient myocardial energy has been considered one of the mechanisms underlying the occu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Publication date: September 2020Source: American Heart Journal, Volume 227Author(s): Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, Pablo Martinez-Amezcua, Alejandro Cabello-López, Gabriela Alanis-Estrada, Abraham Luna-Herbert, Héctor González-Pacheco, Cynthia Paola Paredes-Paucar, Martinez Daniel Sierra-Lara, Jose Luis Briseño-De la Cruz, Hugo Rodriguez-Zanella, Marco Antonio Martinez-Rios, Alexandra Arias-Mendoza
Source: American Heart Journal - Category: Cardiology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Abstract Adeno-associated virus (AAV) has emerged as the vector of choice for delivering genes to the mammalian retina. From the first gene therapy to receive FDA approval for the inherited retinal disease (Luxturna™) to more recent clinical trials using microbial opsins to regain light sensitivity, therapeutic transgenes rely on AAV vectors for safe and efficient gene delivery to retinal cells. Such vectors are administered to the retina via subretinal (SR) injection or intravitreal (IVT) injection routes depending on the targeted retinal cell type. An attractive target for gene therapy is the fovea, bearin...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
m D Abstract Optogenetics, that is, the use of photoswitchable/-activatable moieties to precisely control or monitor the activity of cells and genes at unprecedented spatiotemporal resolution, holds tremendous promise for a wide array of applications in fundamental and clinical research. To fully realize and harness this potential, the availability of gene transfer vehicles ("vectors") that are easily produced and that allow to deliver the essential components to desired target cells in an efficient manner is key. For in vivo applications, it is, moreover, important that these vectors exhibit a high degr...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Publication date: Available online 11 July 2020Source: CarbonAuthor(s): Jingyi Cai, Wenxuan Wang, Wenchao Xie, Xin Wei, Hu Liu, Suying Wei, Hongbo Gu, Zhanhu Guo
Source: Carbon - Category: Materials Science Source Type: research
Authors: Yang B, Sun K, Hui Y, Zhu L, Wang S, Ma S, Yu Z, Zhao J, Liu Q, Zhao J, Chen X Abstract AIM: To investigate whether endoscopic treatment is applicable to American patients and explores the predictors of lymph node metastasis (LNM) in early gastric cancer (EGC). METHODS: Patients with EGC confined to either mucosa (T1a, n = 1799) and submucosa (T1b, n = 1689) were identified from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression, Kaplan-Meier method, and univariate/multivariate Cox regression were used to assess the correlation between ...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Authors: Balogh E, Wagner Z, Faubl N, Riemenschneider H, Voigt K, Terebessy A, Horváth F, Füzesi Z, Kiss I Abstract BACKGROUND: Use of electronic cigarettes (e-cigarettes) is gaining popularity among young adults. Medical students' nicotine use behavior is of particular interest because of their impending role in health promotion. Objectives: Aim of our study is to assess changes that occurred between 2016 and 2018 in the prevalence of e-cigarette use among medical students and to explore associations between e-cigarette use, demographic characteristics, and cigarette smoking. Self-administered question...
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusions: Young PWID inject alone for a variety of reasons, putting them at increased risk of fatal overdose. These findings demonstrate that "don't use alone" messages may not be sufficient given the complex realities of PWID's injection practices. Harm reduction programs employing such messaging should also offer alternative options for overdose prevention/risk reduction for those who do inject alone. PMID: 32646279 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusions: Licensed healthcare professionals are punished differently for similar SUD-related offenses. Further research should explore these differences to identify evidenced based ways to protect the public while assisting this special at-risk population to recover from SUD. PMID: 32646278 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
CONCLUSION: NH African American women had significantly higher cervical cancer incidence and mortality rates than NH Whites. Even as incidence and mortality trends declined significantly, older NH African Americans had three times the rate of cervical cancer than NH Whites. Prevention and treatment programs need to be enhanced for African Americans as failure to do so may widen cancer disparities. PMID: 32651038 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
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