Modulation of the solubility properties of arene ruthenium complexes bearing stannyl ligands as potential anti-cancer agents

Publication date: Available online 8 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Clara Berg, Suviti Chari, Kaste Jurgaityte, Alice Laurora, Mateusz Naldony, Frances Pope, Dario Romano, Thato Medupe, Sharon Prince, Siyabonga Ngubane, Judith Baumgartner, Burgert BlomAbstractCleavage of the known ruthenium dimer [RuCl2(η6-C6H5OCH2CH2OH)]2 (1), bearing a hydrophilic substituent on the η6 coordinated aromatic ring, with the phosphine ligands: triphenyl phosphine, triphenyl phosphite, trimethyl phosphite, and 1,3,5-triaza-7-phosphaadamantane (PTA) afforded the known complexes [RuCl2(η6-C6H5OCH2CH2OH) (PPh3)] (2a), [RuCl2(η6-C6H5OCH2CH2OH){P(OPh)3}] (2b), [RuCl2(η6-C6H5OCH2CH2OH){P(OMe3)}] (2c), and [RuCl2 (η6-C6H5OCH2CH2OH) (PTA)] (4). The reaction of the known complex 2a with SnCl2 afforded, by facile insertion of the SnCl2 moiety into the RuCl bond, the novel complex [RuCl(η6-C6H5OCH2CH2OH) (PPh3) (SnCl3)] (3a). Similarly, the reaction of complex 2b with SnCl2 afforded the novel complex [RuCl(η6-C6H5OCH2CH2OH){P(OPh)3}(SnCl3)] (3b). Complexes 3a and 3b were fully characterized by spectroscopy (Infrared (IR) -spectroscopy, 1H, 31P and 119Sn Nuclear Magnetic Resonance (NMR) spectroscopy, UV–Vis spectroscopy and high resolution ESI-MS) and their thermal behaviour elucidated by Thermogravimetric Analysis (TGA). Density Functional Theory (DFT) calculations (Level of theory B3LYP, basis set for H, C, P, O, N and Cl is 6-31 + G (d,p) and for Ru and Sn is ...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research