Design of organoruthenium complexes for nanoparticle functionalization

We report a ligand with a catechol group based on a picolinamide which allows for coordination to organoruthenium moieties while the catechol group remains available for loading on nanoparticles as delivery vehicles towards tumors. All the compounds were characterized with standard analytical methods and the molecular structures of the ligand 1, and its Ru complexes 1a and 1b were determined by X-ray diffraction analysis. The crystal structure of 1a and 1b showed pseudo-octahedral geometry of the Ru center with “piano-stool” conformation and 1 coordinated as an N,O-bidentate ligand, however, the latter depending on the reaction conditions employed. The Ru complexes 1a–1c were effectively loaded on magnetite nanoparticles as characterized by inductively-coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR).Graphical abstractThe functionalization of a picolinamide-derived ligand with a catechol group led to organoruthenium compounds that could be loaded on iron oxide nanoparticles. Nanoparticle modification was characterized by inductively-coupled plasma mass spectrometry, transmission electron microscopy and Fourier transform infrared spectroscopy.
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research