Axonopathy likely initiates neuropathological processes via a mechanism of axonal leakage in Alzheimer's mouse models.

CONCLUSION: These data provide an explanation for the common origin and development of SPs and NFTs, and suggest that axonal leakage might be a key event in the development of the neuropathological processes in AD.
PMID: 30961496 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - April 4, 2019 Category: Molecular Biology Authors: Gao G, He J, Luo Y, Sun Y, Zhou Y, Zhang J, Xing Y, Dai J Tags: Curr Mol Med Source Type: research