Development of Fibrates as Important Scaffold in Medicinal Chemistry.

Development of Fibrates as Important Scaffold in Medicinal Chemistry.
ChemMedChem. 2019 Apr 08;:
Authors: Giampietro L, Ammazzalorso A, Amoroso R, De Filippis B
Abstract
Fibrates are a class of phenoxy-isobutyric acid derivatives mainly used as antihyperlipidemic agents. The fibrates scaffold has undergone a variety of chemical modifications providing a wide spectrum of biological activities. Within the last years, the majority of new synthetic fibrates derivatives have demonstrated hypolipidemic activity by the PPARα activation. However, some compounds containing fibrate scaffold have shown different pharmacological properties, also independent from PPARα activation, such as anti-inflammatory, analgesic, anti-oxidant and antiplatelet. The aim of this review is to highlight the structure-activity relationships (SAR) to evaluate the significance of fibrates in the field of medicinal chemistry.
PMID: 30957432 [PubMed - as supplied by publisher]

Source: ChemMedChem - April 7, 2019 Category: Chemistry Authors: Giampietro L, Ammazzalorso A, Amoroso R, De Filippis B Tags: ChemMedChem Source Type: research