Century-old bacteria from sick soldier offer clues to cholera epidemics
Scientists have mapped the genome of a strain of cholera extracted a century ago from a sick British soldier during World War One and found clues to how some cholera bacteria strains cause epidemics today.
Conclusions/significanceThe implementation of a nationwide case-area targeted rapid response strategy to control cholera in Haiti was feasible albeit with certain obstacles. Such feedback from the field and ongoing impact studies will be very informative for actors and international donors involved in cholera control and elimination in Haiti and in other affected countries.
Conclusion The aim of our study was to determine if STs and virulence gene profiles of clinical and environmental V. cholerae non-O1, non-O139 strains originating from German coastal waters may be correlated and could be usable for a risk assessment of individual strains. The result of this study reveals that – given on the current knowledge about the potential pathogenicity of these strains – no such correlation is found. The MLST shows a high diversity of the bacteria, whereas a basic equipment with virulence genes is very similar between all strains. Due to horizontal gene transfer, in some strains the numb...
Scientists have mapped the genome of a strain of cholera from a WW I British soldier. It could provide insights on cholera outbreaks today.
In this study, 12 O-antigen gene clusters of P. shigelloides, O2H1a1c (G5877), O10H41 (G5892), O12H35 (G5890), O23H1a1c (G5263), O25H3 (G5879), O26H1a1c (G5889), O32H37 (G5880), O33H38 (G5881), O34H34 (G5882), O66H3 (G5270), O75H34 (G5885), and O76H39 (G5886), were sequenced and analyzed. The genes that control O-antigen synthesis are present as chromosomal gene clusters that maps between rep and aqpZ, and most of the synthesis and translocation of OPS (O-specific polysaccharide) belongs to Wzx/Wzy pathway with the exception of O12, O25, and O66, which use the ATP-binding cassette (ABC) transporter pathway. Phylogenetic an...
Ellen Waters is the Director of Development at Doctors of the World UK. She is passionate about access to healthcare around the world and spent four years in India working for human rights organisations. On Thursday 14th March, Cyclone Idai swept Mozambique, leaving behind it a trail of destruction and death. Organisations from all around the world mobilised in just a few hours to get help to the population hit. Rapid intervention is key to save lives, but there is an often hidden need to provide healthcare for a long time after the disaster, while reconstruction takes place. On World Health Day, I want to bri...
[VOA] A mass vaccination campaign against cholera has begun in Mozambique to prevent this deadly disease from turning into a full-blown epidemic.
About two million people are displaced, cholera has broken out, and malaria is expected. But doses of cholera vaccine have arrived, and the humanitarian crisis may yet be contained, aid agencies say.
Around 900,000 doses of cholera vaccine arrived in Mozambique on Tuesday to help stave off a possible epidemic, after the devastation caused by Cyclone Idai, amid reports that the disease has already infected more than 1,000 people in affected areas.
Yemeni doctor Mohammed Abdul-Mughni described the surge in cholera cases he was treating as "disastrous" in a country battered by years of war and short of medical staff.
The original version of this article unfortunately contained a mistake. In the introduction, the infectious dose ofVibrio cholerae was written as 103 –108 instead of 103-108 cells.